| Gene Symbol |
API5
|
| Entrez Gene |
8539
|
| Alt Symbol |
AAC-11, AAC11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apoptosis inhibitor 5
|
| Other Description |
FIF|antiapoptosis clone 11 protein|cell migration-inducing gene 8 protein|fibroblast growth factor 2-interacting factor 2|migration-inducing protein MIG8
|
| Swissprots |
O15441 B4DGR0 B4DRJ2 D3DR21 Q9Y4J7 Q9BZZ5 B4E283
|
| Accessions |
AAO89077 EAW68098 EAW68099 Q9BZZ5 AF229253 AAK00737 AF229254 AAK00738 AK021649 AK293303 BAG56824 AK294724 BAG57871 AK299288 BAG61304 AK304157 BAG65045 AY311389 AAQ76714 BC015898 BC017709 AAH17709 BF115210 BM193468 BT007093 AAP35756 CK904611 DA104687 DC334531 DQ890671 ABM81597 DQ893852 ABM84778 U83857 AAB86528 Y15906 CAA75867 XM_006718359 XP_006718422 NM_001142930 NP_001136402 NM_001142931 NP_001136403 NM_001243747 NP_001230676 NM_006595 NP_006586 NR_024625
|
| Function |
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.
|
| Tissue Specificity |
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:11075807, ECO:0000269|PubMed:11557113, ECO:0000269|PubMed:17827341, ECO:0000269|PubMed:19387494}.
|
![Western Blot: API5 Overexpression Lysate (Adult Normal) [NBP2-09675] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for API5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6484_API5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09675-img0001.jpg)