API5

Gene Symbol API5
Entrez Gene 8539
Alt Symbol AAC-11, AAC11
Species Human
Gene Type protein-coding
Description apoptosis inhibitor 5
Other Description FIF|antiapoptosis clone 11 protein|cell migration-inducing gene 8 protein|fibroblast growth factor 2-interacting factor 2|migration-inducing protein MIG8
Swissprots O15441 B4DGR0 B4DRJ2 D3DR21 Q9Y4J7 Q9BZZ5 B4E283
Accessions AAO89077 EAW68098 EAW68099 Q9BZZ5 AF229253 AAK00737 AF229254 AAK00738 AK021649 AK293303 BAG56824 AK294724 BAG57871 AK299288 BAG61304 AK304157 BAG65045 AY311389 AAQ76714 BC015898 BC017709 AAH17709 BF115210 BM193468 BT007093 AAP35756 CK904611 DA104687 DC334531 DQ890671 ABM81597 DQ893852 ABM84778 U83857 AAB86528 Y15906 CAA75867 XM_006718359 XP_006718422 NM_001142930 NP_001136402 NM_001142931 NP_001136403 NM_001243747 NP_001230676 NM_006595 NP_006586 NR_024625
Function Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.
Tissue Specificity Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:11075807, ECO:0000269|PubMed:11557113, ECO:0000269|PubMed:17827341, ECO:0000269|PubMed:19387494}.

API5 CRISPR/Cas9 KO Plasmid (h) - sc-406608 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 HDR Plasmid (h) - sc-406608-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 Double Nickase Plasmid (h) - sc-406608-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 Double Nickase Plasmid (h2) - sc-406608-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 CRISPR Activation Plasmid (h) - sc-406608-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 CRISPR Activation Plasmid (h2) - sc-406608-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 Lentiviral Activation Particles (h) - sc-406608-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 Lentiviral Activation Particles (h2) - sc-406608-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 siRNA (h) - sc-96495 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

API5 shRNA Plasmid (h) - sc-96495-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

API5 shRNA (h) Lentiviral Particles - sc-96495-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

API5 RNAi - H00008539-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU104431 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3318 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3318 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

API5 siRNA (Human) - CRH5610 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

API5 - MBS8210096 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

API5 CRISPR/Cas9 KO Plasmid (h2) - sc-406608-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

API5 HDR Plasmid (h2) - sc-406608-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human API5 siRNA - orb266112 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

API5 shRNA Plasmid (Human) - CHH5610 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

API5 miRNA 3'UTR clone - MiUTR4H-TG00403 from Creative biogene

Species Reactivities Human
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