API5

Gene Symbol	API5
Entrez Gene	8539
Alt Symbol	AAC-11, AAC11
Species	Human
Gene Type	protein-coding
Description	apoptosis inhibitor 5
Other Description	FIF|antiapoptosis clone 11 protein|cell migration-inducing gene 8 protein|fibroblast growth factor 2-interacting factor 2|migration-inducing protein MIG8
Swissprots	O15441 B4DGR0 B4DRJ2 D3DR21 Q9Y4J7 Q9BZZ5 B4E283
Accessions	AAO89077 EAW68098 EAW68099 Q9BZZ5 AF229253 AAK00737 AF229254 AAK00738 AK021649 AK293303 BAG56824 AK294724 BAG57871 AK299288 BAG61304 AK304157 BAG65045 AY311389 AAQ76714 BC015898 BC017709 AAH17709 BF115210 BM193468 BT007093 AAP35756 CK904611 DA104687 DC334531 DQ890671 ABM81597 DQ893852 ABM84778 U83857 AAB86528 Y15906 CAA75867 XM_006718359 XP_006718422 NM_001142930 NP_001136402 NM_001142931 NP_001136403 NM_001243747 NP_001230676 NM_006595 NP_006586 NR_024625
Function	Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.
Tissue Specificity	Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:11075807, ECO:0000269|PubMed:11557113, ECO:0000269|PubMed:17827341, ECO:0000269|PubMed:19387494}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Apoptosis inhibitor 5 protein fragment - ab160084 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

API5 Antibody Blocking Peptide - LS-E6186 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human API5 Protein - H00008539-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

API5-Antibody-C-term-Blocking-Peptide - BP18825b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

API5 peptide - orb218159 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

API5 Blocking Peptide - abx063490 from Abbexa Category Peptide Species Human, Monkey

API5 / MIG8 - H00008539-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

API5 / MIG8 - H00008539-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

API5 fusion protein - Ag22524 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

Recombinant Apoptosis Inhibitor 5 (API5) - RPE234Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

API5 Blocking Peptide - CBP2296 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

Recombinant Apoptosis Inhibitor 5 (API5) - RPE234Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Apoptosis inhibitor 5(API5) - CSB-YP001904HU CSB-EP001904HU CSB-BP001904HU CSB-MP001904HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

API5 Peptide - abx164690 from Abbexa Category Peptide Species Human, Mouse, Rat

Apoptosis Inhibitor 5 Protein (Recombinant) - abx166819 from Abbexa Category Protein Source Human Species Human

API5 / MIG8 (transcript variant 3) - TP327863 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Apoptosis inhibitor 5(API5) , Recombinant Protein - MBS1369085 from MyBioSource Category Protein Prices $2,165.00, $2,165.00, $2,630.00, $2,630.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

API5 Recombinant Protein Antigen - NBP1-89326PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

API5 Peptide, Human - M34GP00755H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Apoptosis Inhibitor 5 (API5) - RPU52476 from Biomatik Category Protein Prices $188.00, $385.00, $589.00, $701.92 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

API5 Recombinant Protein (OPCD01389) - OPCD01389 from Aviva Systems Biology Category Protein Source E.coli Species Human

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