API5

Gene Symbol API5
Entrez Gene 8539
Alt Symbol AAC-11, AAC11
Species Human
Gene Type protein-coding
Description apoptosis inhibitor 5
Other Description FIF|antiapoptosis clone 11 protein|cell migration-inducing gene 8 protein|fibroblast growth factor 2-interacting factor 2|migration-inducing protein MIG8
Swissprots O15441 B4DGR0 B4DRJ2 D3DR21 Q9Y4J7 Q9BZZ5 B4E283
Accessions AAO89077 EAW68098 EAW68099 Q9BZZ5 AF229253 AAK00737 AF229254 AAK00738 AK021649 AK293303 BAG56824 AK294724 BAG57871 AK299288 BAG61304 AK304157 BAG65045 AY311389 AAQ76714 BC015898 BC017709 AAH17709 BF115210 BM193468 BT007093 AAP35756 CK904611 DA104687 DC334531 DQ890671 ABM81597 DQ893852 ABM84778 U83857 AAB86528 Y15906 CAA75867 XM_006718359 XP_006718422 NM_001142930 NP_001136402 NM_001142931 NP_001136403 NM_001243747 NP_001230676 NM_006595 NP_006586 NR_024625
Function Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.
Tissue Specificity Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:11075807, ECO:0000269|PubMed:11557113, ECO:0000269|PubMed:17827341, ECO:0000269|PubMed:19387494}.

API5 (D-1) - sc-393341 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
API5 (D-1): sc-393341. Western blot analysis of API5 expression in HeLa (A) and SW480 (B) whole cell lysates.

API5 (E-12) - sc-374528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
API5 (E-12): sc-374528. Western blot analysis of API5 expression in Y79 (A) and A549 (B) nuclear extracts.

API5 (H-300) - sc-135080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
API5 (H-300): sc-135080. Western blot analysis of API5 expression in non-transfected: sc-117752 (A) and human API5 transfected: sc-113428 (B) 293T whole cell lysates and Y79 (C) and WI 38 (D) nuclear extracts.

API5 (N-13) - sc-167094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
API5 (N-13): sc-167094. Western blot analysis of API5 expression in Y79 nuclear extract.

API5 (T-14) - sc-167096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

API5 (Z-18) - sc-101203 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
API5 (Z-18): sc-101203. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human small Intestine tissue showing nuclear localization.

Anti-Apoptosis inhibitor 5 antibody - ab65068 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Apoptosis inhibitor 5 antibody (ab65068) at 1/500 dilutionLane 1 : extracts from 293 cellsLane 2 : extracts from Jurkat cellsLane 3 : extracts from HuvEc cellsLane 4 : extracts from HuvEc cells with immunizing peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Apoptosis inhibitor 5 antibody - ab65836 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human epidermal carcinoma tissue stained with ab65836 at 0.5-1µg/ml.

Anti-Apoptosis inhibitor 5 antibody - ab99307 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling Apoptosis inhibitor 5 with ab99307 at 1/1000 (0.2µg/mg) and 1/200 (1 µg/mg). Detection: DAB.

Anti-Apoptosis inhibitor 5 antibody - ab56392 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Apoptosis inhibitor 5 antibody (ab56392) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

Anti-Apoptosis inhibitor 5 antibody - ab99308 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling Apoptosis inhibitor 5 with ab99308 at 1/5000 (0.2µg/mg). Detection: DAB.

Anti-API5 Antibody (aa481-510) - LS-C319537 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (aa400-504, Azide-free) - LS-C326858 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-API5 Antibody (aa1-50) - LS-C289498 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse API5 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-API5 used at a dilution of 1:1000 (0.2 ug/mg) and 1:200 (1 ug/mg).

Anti-API5 Antibody (aa421-470) IHC-plus™ - LS-B8532 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-API5 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8532 dilution 5 ug/ml.

Anti-API5 Antibody (aa150-200) - LS-C289499 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse API5 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-API5 used at a dilution of 1:5000 (0.2 ug/mg).

Anti-API5 Antibody (aa478-492) - LS-C121355 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (C-Terminus) - LS-C121188 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (C-Terminus, Magnetic beads) - LS-C171656 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (C-Terminus, Sepharose) - LS-C171657 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (aa482-510, AP) - LS-C251513 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (aa482-510) - LS-C159090 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
API5 Antibody western blot of CEM cell line lysates (35 ug/lane). The API5 antibody detected the API5 protein (arrow).

Anti-API5 Antibody (aa482-510, APC) - LS-C251515 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (aa482-510, Biotin) - LS-C251516 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-API5 Antibody (aa482-510, FITC) - LS-C251517 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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