TNFSF13B

Gene Symbol	TNFSF13B
Entrez Gene	10673
Alt Symbol	BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 13b
Other Description	ApoL related ligand TALL-1|B-cell-activating factor|B-lymphocyte stimulator|Delta4 BAFF|TNF and ApoL-related leukocyte expressed ligand 1|TNF homolog that activates apoptosis|delta BAFF|dendritic cell-derived TNF-like molecule|tumor necrosis factor (ligand) superfamily, member 20|tumor necrosis factor ligand superfamily member 13B|tumor necrosis factor-like protein ZTNF4
Swissprots	Q9Y275 Q6FHD6 Q7Z5J2 E0ADT7
Accessions	ABK41889 BAB90856 EAX09099 EAX09100 EAX09101 Q9Y275 AF116456 AAD25356 AF132600 AAD21092 AF134715 AAF60219 AF136293 AAD29421 AF186114 AAF01432 AK309629 AW151367 AW963062 AY129225 AAN08421 AY129226 AAN08422 AY129227 AAN08423 AY129228 AAN08424 AY302751 AAP83164 AY358881 AAQ89240 BC020674 AAH20674 BI818459 BQ776352 BQ778438 BX482686 CR541818 CAG46617 D79690 DQ857728 DQ891413 ABM82339 EU176634 ABW03435 HM636064 ADK91575 XM_005254029 XP_005254086 NM_001145645 NP_001139117 NM_006573 NP_006564
Function	Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}.
Top Pathways	Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BAFF (TNFSF13B) Human ELISA Kit - ab119579 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 2 pg/ml Range 62.5 pg/ml - 4000 pg/ml

BAFF (TNFSF13B) Human SimpleStep ELISA™ Kit - ab188391 from Abcam Category ELISA Kit Prices $484.00 Sizes 1 x 96 tests Sensitivity 12.7 pg/ml Range 0.08 ng/ml - 5 ng/ml

Mouse BAFF ELISA Kit (Sandwich ELISA) - LS-F6462 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 26.1 pg/ml Range 62.5-4000 pg/ml

Mouse BAFF ELISA Kit (Sandwich ELISA) - LS-F2613 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 62.5-4000 pg/ml

Human BAFF ELISA Kit (Sandwich ELISA) - LS-F2612 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 2 pg/ml Range 62.5-4000 pg/ml

Human BAFF ELISA Kit (Sandwich ELISA) - LS-F4905 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 34 pg/ml Range 62.5-4000 pg/ml

Rat BAFF ELISA Kit (Sandwich ELISA) - LS-F7155 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 27 pg/ml Range 62.5-4000 pg/ml

Mouse BAFF ELISA Kit (Sandwich ELISA) - LS-F12786 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 78 Range 62.5-4000 pg/ml

Human BAFF ELISA Kit (Sandwich ELISA) - LS-F12785 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.312 Range 62.5-4000 pg/ml

Human BAFF/BLyS/TNFSF13B Luminex Performance Assay - LBA124 from R&D Systems

Human BAFF/BLyS/TNFSF13B Quantikine ELISA Kit - DBLYS0B from R&D Systems Category ELISA Kit Prices $519.00, $2,491.00, $16,868.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 6.44 pg/mL Range 62.5 - 4,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human BAFF/BLyS/TNFSF13B Quantikine PharmPak (50 Plates) - PDBLYS0B from R&D Systems Category ELISA Kit Sensitivity 6.44 pg/mL Range 62.5 - 4,000 pg/mL (Serum, Heparin Plasma, Cell Culture Supernates, EDTA Plasma)

Human BAFF/BLyS/TNFSF13B Quantikine SixPak (6 Plates) - SBLYS0B from R&D Systems Category ELISA Kit Sensitivity 6.44 pg/mL Range 62.5 - 4,000 pg/mL (Serum, Heparin Plasma, Cell Culture Supernates, EDTA Plasma)

Mouse BAFF/BLyS/TNFSF13B Quantikine ELISA Kit - MBLYS0 from R&D Systems Category ELISA Kit Prices $479.00 Sizes 1 kit Sensitivity 7.8 pg/mL Range 46.9 - 3,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)

Human BAFF/BLyS/TNFSF13B DuoSet ELISA - DY124-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 39.10 - 2,500 pg/mL

Mouse BAFF/BLyS/TNFSF13B DuoSet ELISA - DY2106-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 62.50 - 4,000 pg/mL

Quantikine Immunoassay Control Set 734 for Human BAFF/BLyS - QC46 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human BAFF ELISA Kit - 55R-1727 from Fitzgerald Category ELISA Kit Prices $440.00 Sizes 1 kit

Mouse BAFF ELISA Kit - 55R-1728 from Fitzgerald Category ELISA Kit Prices $440.00 Sizes 1 kit

Human BAFF ELISA Kit - abx150781 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human BAFF ELISA kit - abx050009 from Abbexa Category ELISA Kit Sensitivity < 2pg/ml Range 62.5 pg/ml-4000 pg/ml

Human CD257 ELISA Kit - abx056084 from Abbexa Category ELISA Kit

B cell activation factor_BAFF, Human, ELISA Kit - CSB-E11912h from ARP American Research Products Category ELISA Kit Prices $565.00, $835.00, $837.00, $839.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

B-Cell Activating Factor (BAFF), Human, ELISA Kit - SEB686Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.055ng/mL Range 0.156-10ng/mL

B-Cell Activating Factor (BAFF), Human, ELISA Kit - PB-0663 from ARP American Research Products Category ELISA Kit Prices $449.00 Sizes 96 t Sensitivity < 2 pg/ml Range 62.5pg/ml-4000pg/ml

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