TNFSF13B

Gene Symbol	TNFSF13B
Entrez Gene	10673
Alt Symbol	BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 13b
Other Description	ApoL related ligand TALL-1|B-cell-activating factor|B-lymphocyte stimulator|Delta4 BAFF|TNF and ApoL-related leukocyte expressed ligand 1|TNF homolog that activates apoptosis|delta BAFF|dendritic cell-derived TNF-like molecule|tumor necrosis factor (ligand) superfamily, member 20|tumor necrosis factor ligand superfamily member 13B|tumor necrosis factor-like protein ZTNF4
Swissprots	Q9Y275 Q6FHD6 Q7Z5J2 E0ADT7
Accessions	ABK41889 BAB90856 EAX09099 EAX09100 EAX09101 Q9Y275 AF116456 AAD25356 AF132600 AAD21092 AF134715 AAF60219 AF136293 AAD29421 AF186114 AAF01432 AK309629 AW151367 AW963062 AY129225 AAN08421 AY129226 AAN08422 AY129227 AAN08423 AY129228 AAN08424 AY302751 AAP83164 AY358881 AAQ89240 BC020674 AAH20674 BI818459 BQ776352 BQ778438 BX482686 CR541818 CAG46617 D79690 DQ857728 DQ891413 ABM82339 EU176634 ABW03435 HM636064 ADK91575 XM_005254029 XP_005254086 NM_001145645 NP_001139117 NM_006573 NP_006564
Function	Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}.
Top Pathways	Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TNFSF13B-Over-expression-Lysate - LY10452a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CD257 / BAFF Lysate(Denatured) - H00010673-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

TNFSF13B overexpression lysate - LY401966 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TNFSF13B 293 Cell Lysate - 401749 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

BAFF/BLyS/TNFSF13B Overexpression Lysate (Denatured) - H00010673-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

BAFF/BLyS/TNFSF13B Overexpression Lysate (Native) - NBL1-17166 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TALL-1 (h): 293T Lysate - sc-176656 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

TNFSF13B Over-expression Lysate Product - GWB-4317A5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cynomolgus BLyS / TNFSF13B / BAFF HEK293 Cell Lysate (WB positive control) - 90267-C01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human BLyS / TNFSF13B / BAFF HEK293 Cell Lysate (WB positive control) - 10056-HNCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BLyS / TNFSF13B / BAFF HEK293 Cell Lysate (WB positive control) - 10056-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human BAFF Human Cells Transfected Lysate (positive control) (denatured) - orb173720 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human BAFF Human Cells Transfected Lysate (positive control) (denatured) - orb173262 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human TNFSF13B Knockdown Stable Cell Line - CSC-DC016376 from Creative biogene Category Cell Line Species Human

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