TNFSF13B

Gene Symbol	TNFSF13B
Entrez Gene	10673
Alt Symbol	BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor (ligand) superfamily, member 13b
Other Description	ApoL related ligand TALL-1|B-cell-activating factor|B-lymphocyte stimulator|Delta4 BAFF|TNF and ApoL-related leukocyte expressed ligand 1|TNF homolog that activates apoptosis|delta BAFF|dendritic cell-derived TNF-like molecule|tumor necrosis factor (ligand) superfamily, member 20|tumor necrosis factor ligand superfamily member 13B|tumor necrosis factor-like protein ZTNF4
Swissprots	Q9Y275 Q6FHD6 Q7Z5J2 E0ADT7
Accessions	ABK41889 BAB90856 EAX09099 EAX09100 EAX09101 Q9Y275 AF116456 AAD25356 AF132600 AAD21092 AF134715 AAF60219 AF136293 AAD29421 AF186114 AAF01432 AK309629 AW151367 AW963062 AY129225 AAN08421 AY129226 AAN08422 AY129227 AAN08423 AY129228 AAN08424 AY302751 AAP83164 AY358881 AAQ89240 BC020674 AAH20674 BI818459 BQ776352 BQ778438 BX482686 CR541818 CAG46617 D79690 DQ857728 DQ891413 ABM82339 EU176634 ABW03435 HM636064 ADK91575 XM_005254029 XP_005254086 NM_001145645 NP_001139117 NM_006573 NP_006564
Function	Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}.
Top Pathways	Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BAFF (D7I1U) Rabbit mAb - 19944 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D7I1U

TALL-1 (A-9) - sc-271809 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TALL-1 (6F2) - sc-32773 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TALL-1 (B-6) - sc-271198 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

TALL-1 (L-16) - sc-5742 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

TALL-1 (H-230) - sc-25438 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

TALL-1 (C-16) - sc-5744 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-BAFF antibody - ab8396 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BAFF antibody - ab109568 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BAFF antibody - ab189836 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BAFF antibody - ab68345 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BAFF antibody - ab9359 from Abcam Prices $376.00 Sizes 500 µg Host Mouse Clonality Monoclonal

Anti-BAFF antibody - ab191312 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BAFF antibody (Biotin) - ab83511 from Abcam Prices $370.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-BAFF antibody [Buffy 2] - ab16081 from Abcam Prices $390.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone Buffy 2

Anti-BAFF antibody [Buffy 2] (FITC) - ab16082 from Abcam Prices $189.00 Sizes 50 tests Host Rat Clonality Monoclonal Clone Buffy 2

Anti-BAFF antibody [Buffy XI] - ab16087 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone Buffy XI

Anti-BAFF antibody [MM0106-8K16] - ab89139 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone MM0106-8K16

Anti-BAFF antibody [T7-241] - ab115297 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone T7-241

Anti-BAFF Antibody (aa16-44, PE) - LS-C271893 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAFF Antibody (aa16-44, Azide-free, HRP) - LS-C271894 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BAFF Antibody (aa68-302, Biotin) - LS-C300116 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BAFF Antibody (aa83-285, clone Buffy-1) IHC-plus™ - LS-B2375 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone Buffy-1

Anti-BAFF Antibody (aa254-269) IHC-plus™ - LS-B2081 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BAFF Antibody - LS-C104387 from LifeSpan Bioscience Prices $285.00, $325.00 Sizes 50 µg, 100 µg Host Goat Clonality Polyclonal

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