TNFSF13B
| Gene Symbol | TNFSF13B |
|---|---|
| Entrez Gene | 10673 |
| Alt Symbol | BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, ZTNF4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor (ligand) superfamily, member 13b |
| Other Description | ApoL related ligand TALL-1|B-cell-activating factor|B-lymphocyte stimulator|Delta4 BAFF|TNF and ApoL-related leukocyte expressed ligand 1|TNF homolog that activates apoptosis|delta BAFF|dendritic cell-derived TNF-like molecule|tumor necrosis factor (ligand) superfamily, member 20|tumor necrosis factor ligand superfamily member 13B|tumor necrosis factor-like protein ZTNF4 |
| Swissprots | Q9Y275 Q6FHD6 Q7Z5J2 E0ADT7 |
| Accessions | ABK41889 BAB90856 EAX09099 EAX09100 EAX09101 Q9Y275 AF116456 AAD25356 AF132600 AAD21092 AF134715 AAF60219 AF136293 AAD29421 AF186114 AAF01432 AK309629 AW151367 AW963062 AY129225 AAN08421 AY129226 AAN08422 AY129227 AAN08423 AY129228 AAN08424 AY302751 AAP83164 AY358881 AAQ89240 BC020674 AAH20674 BI818459 BQ776352 BQ778438 BX482686 CR541818 CAG46617 D79690 DQ857728 DQ891413 ABM82339 EU176634 ABW03435 HM636064 ADK91575 XM_005254029 XP_005254086 NM_001145645 NP_001139117 NM_006573 NP_006564 |
| Function | Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}. |
| Subcellular Location | Cell membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis |
TALL-1 CRISPR/Cas9 KO Plasmid (h) - sc-406502 from Santa Cruz Biotechnology
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TALL-1 HDR Plasmid (h) - sc-406502-HDR from Santa Cruz Biotechnology
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TALL-1 Double Nickase Plasmid (h) - sc-406502-NIC from Santa Cruz Biotechnology
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TALL-1 Double Nickase Plasmid (h2) - sc-406502-NIC-2 from Santa Cruz Biotechnology
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TALL-1 CRISPR Activation Plasmid (h) - sc-406502-ACT from Santa Cruz Biotechnology
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TALL-1 CRISPR Activation Plasmid (h2) - sc-406502-ACT-2 from Santa Cruz Biotechnology
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TALL-1 Lentiviral Activation Particles (h) - sc-406502-LAC from Santa Cruz Biotechnology
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TALL-1 Lentiviral Activation Particles (h2) - sc-406502-LAC-2 from Santa Cruz Biotechnology
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TALL-1 siRNA (h) - sc-39830 from Santa Cruz Biotechnology
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TALL-1 shRNA Plasmid (h) - sc-39830-SH from Santa Cruz Biotechnology
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TALL-1 shRNA (h) Lentiviral Particles - sc-39830-V from Santa Cruz Biotechnology
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BAFF/BLyS/TNFSF13B RNAi - H00010673-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21764 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21764 from Sigma-Aldrich
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TNFSF13B siRNA (Human) - CRH7280 from Cohesion Biosciences
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TNFSF13B - MBS8212083 from MyBioSource
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TALL-1 CRISPR/Cas9 KO Plasmid (h2) - sc-406502-KO-2 from Santa Cruz Biotechnology
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TALL-1 HDR Plasmid (h2) - sc-406502-HDR-2 from Santa Cruz Biotechnology
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Human TNFSF13B siRNA - orb267782 from Biorbyt
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TNFSF13B shRNA Plasmid (Human) - CHH7280 from Cohesion Biosciences
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TNFSF13B miRNA 3'UTR clone - MiUTR3H-06419 from Creative biogene
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TNFSF13B miRNA 3'UTR clone - MiUTR3H-06420 from Creative biogene
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