FGB

Gene Symbol FGB
Entrez Gene 2244
Alt Symbol HEL-S-78p
Species Human
Gene Type protein-coding
Description fibrinogen beta chain
Other Description epididymis secretory sperm binding protein Li 78p|fibrinogen, B beta polypeptide
Swissprots B2R7G3 A0JLR9 Q32Q65 Q3KPF2 P02675
Accessions AAA18024 AAA98115 AAA98116 AAK62470 CAA28674 CDL78902 EAX04930 EAX04931 EAX04932 EAX04933 EAX04934 EAX04935 EAX04936 EAX04937 EAX04938 EAX04939 P02675 AI174804 AK303788 BAG64745 AK309592 AK311683 AK312972 BAG35810 BC007030 AAH07030 BC036007 BC060040 BC070245 BC106760 AAI06761 BC107766 AAI07767 EU668333 ACF94486 J00129 AAA52429 J00133 T74412 NM_001184741 NP_001171670 NM_005141 NP_005132
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Subcellular Location Secreted.
Top Pathways Complement and coagulation cascades

Fibrinogen β (C-1) - sc-271017 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibrinogen β (C-1): sc-271017. Western blot analysis of full length human recombinant Fibrinogen β.

Fibrinogen β (C-20) - sc-18029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fibrinogen β (C-20): sc-18029. Western blot analysis of 25 ng (A) and 50 ng (B) of human Fibrinogen β.

Fibrinogen β (E-5) - sc-271018 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Fibrinogen β (E-5): sc-271018. Western blot analysis of full length human recombinant Fibrinogen β.

Fibrinogen β (H-270) - sc-33581 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Fibrinogen β (H-270): sc-33581. Western blot analysis of Fibrinogen β expression in c4 whole cell lysate (A) and full length human recombinant Fibrinogen β (B).

Fibrinogen β (I-18) - sc-18027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Fibrinogen β (I-18): sc-18027. Western blot analysis of human Fibrinogen β.

Anti-Fibrinogen beta chain antibody [1F9] - ab86455 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1F9
Anti-Fibrinogen beta chain antibody [1F9] (ab86455) at 1/500 dilution + Human plasma

Anti-Fibrinopeptide B antibody - ab198560 from Abcam

Prices $370.00
Sizes 150 µg
Host Rabbit
Clonality Polyclonal

Anti-Fibrinopeptide B antibody [1F9] - ab110062 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1F9
Anti-Fibrinopeptide B antibody [1F9] (ab110062) at 1/500 dilution + Human plasma

Anti-Fibrinopeptide B antibody (Biotin) - ab48257 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Fibrinopeptide B antibody [EPR3082] - ab92510 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3082
All lanes : Anti-Fibrinopeptide B antibody [EPR3082] (ab92510) at 1/5000 dilutionLane 1 : Human prostate lysateLane 2 : Human plasma lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Fibrinopeptide B antibody [EPR3083] - ab133359 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3083
All lanes : Anti-Fibrinopeptide B antibody [EPR3083] (ab133359) at 1/1000 dilutionLane 1 : Human plasma lysateLane 2 : Human prostate lysateLane 3 : Rat platelet lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Fibrinopeptide B antibody - C-terminal - ab86572 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Fibrinopeptide B antibody - C-terminal (ab86572) at 1/50 dilution + Mouse liver tissue lysate at 35 µg

Anti-FGB / Fibrinogen Beta Chain Antibody (clone 1F9) IHC-plus™ - LS-B3863 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 1F9
Anti-FGB / Fibrinogen Beta Chain antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3863 dilution 1:200.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa177-190) IHC-plus™ - LS-B11267 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-FGB antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FGB / Fibrinogen Beta Chain Antibody - LS-C23588 from LifeSpan Bioscience

Prices $545.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal

Anti-FGB Antibody (Thr417) - LS-C193222 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FGB / Fibrinogen Beta Chain Antibody (aa45-491) - LS-C292425 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Western blot of recombinant FGB.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa106-155) - LS-C201412 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human MCF7. FGB antibody dilution 1.0 ug/ml.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa35-481) - LS-C294154 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FGB.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa45-491) - LS-C294153 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant FGB.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa330-357) IHC-plus™ - LS-B6670 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FGB / Fibrinogen Beta Chain antibody IHC of human small intestine, intravascular plasma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6670 concentration 10 ug/ml.

Anti-FGB Antibody - LS-C192776 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts of mouse heart tissue cell lines, using FGB antibody.

Anti-FGB / Fibrinogen Beta Chain Antibody (aa29-58) - LS-C99235 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FIBB Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-FGB Antibody (C-Terminus, clone EPR3083) - LS-C105566 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3083
Immunofluorescent staining of HeLa cells using anti-Fibrinogen beta chain antibody (LS-C105566).

Anti-FGB / Fibrinogen Beta Chain Antibody (aa49-495, Biotin) - LS-C297083 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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