| Gene Symbol | FGB |
|---|---|
| Entrez Gene | 2244 |
| Alt Symbol | HEL-S-78p |
| Species | Human |
| Gene Type | protein-coding |
| Description | fibrinogen beta chain |
| Other Description | epididymis secretory sperm binding protein Li 78p|fibrinogen, B beta polypeptide |
| Swissprots | B2R7G3 A0JLR9 Q32Q65 Q3KPF2 P02675 |
| Accessions | AAA18024 AAA98115 AAA98116 AAK62470 CAA28674 CDL78902 EAX04930 EAX04931 EAX04932 EAX04933 EAX04934 EAX04935 EAX04936 EAX04937 EAX04938 EAX04939 P02675 AI174804 AK303788 BAG64745 AK309592 AK311683 AK312972 BAG35810 BC007030 AAH07030 BC036007 BC060040 BC070245 BC106760 AAI06761 BC107766 AAI07767 EU668333 ACF94486 J00129 AAA52429 J00133 T74412 NM_001184741 NP_001171670 NM_005141 NP_005132 |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}. |
| Subcellular Location | Secreted. |
| Top Pathways | Complement and coagulation cascades |