FGB

Gene Symbol	FGB
Entrez Gene	2244
Alt Symbol	HEL-S-78p
Species	Human
Gene Type	protein-coding
Description	fibrinogen beta chain
Other Description	epididymis secretory sperm binding protein Li 78p|fibrinogen, B beta polypeptide
Swissprots	B2R7G3 A0JLR9 Q32Q65 Q3KPF2 P02675
Accessions	AAA18024 AAA98115 AAA98116 AAK62470 CAA28674 CDL78902 EAX04930 EAX04931 EAX04932 EAX04933 EAX04934 EAX04935 EAX04936 EAX04937 EAX04938 EAX04939 P02675 AI174804 AK303788 BAG64745 AK309592 AK311683 AK312972 BAG35810 BC007030 AAH07030 BC036007 BC060040 BC070245 BC106760 AAI06761 BC107766 AAI07767 EU668333 ACF94486 J00129 AAA52429 J00133 T74412 NM_001184741 NP_001171670 NM_005141 NP_005132
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
Subcellular Location	Secreted.
Top Pathways	Complement and coagulation cascades

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Fibrinopeptide B protein fragment - ab158433 from Abcam Category Protein Source Wheat germ Species Human

Human Fibrinopeptide B protein fragment - ab202189 from Abcam Category Protein Source E. coli Species Human

FGB / Fibrinogen Beta Chain Antibody Blocking Peptide - LS-E8251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FGB / Fibrinogen Beta Chain Antibody Blocking Peptide - LS-E8252 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Fibrinopeptide B Partial Recombinant Protein - H00002244-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FIBB-Antibody-C-term-Blocking-Peptide - BP6517b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FIBB-Antibody-N-term-Blocking-Peptide - BP6517a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Fibrinogen-Beta-Chain-24-42 - SP2637b from Abgent, a WuXi AppTec company Category Peptide Prices $205.00 Sizes 5 mg

Fibrinogen-Beta-Chain-24-42 - SP2637a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

Fibrinopeptide-B-human - SP3493b from Abgent, a WuXi AppTec company Category Peptide Prices $205.00 Sizes 5 mg Species Human

Fibrinopeptide-B-human - SP3493a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg Species Human

FGB protein - 80R-4232 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

Human FGB Protein - abx060020 from Abbexa Category Protein Source Yeast Species Human

Human Fibrinogen Beta Protein - abx066576 from Abbexa Category Protein Source E.coli Species Human

Human Fibrinogen Beta Protein - abx066572 from Abbexa Category Protein Source E.coli Species Human

Fibrinogen beta chain (164-491, His-tag) - AR51914PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Fibrinogen beta chain (164-491, His-tag) - AR51914PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Fibrinogen beta chain - H00002244-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Fibrinogen beta chain - H00002244-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Fibrinogen Beta (FGb), Human - 20-7547 from ARP American Research Products Category Protein Prices $419.00 Sizes 50 µg Source E.coli Species Human

Fibrinogen Beta (FGb), Human - 20-7548 from ARP American Research Products Category Protein Prices $419.00 Sizes 50 µg Source E.coli Species Human

Fibrinogen Beta (FGb), Human - 20-7549 from ARP American Research Products Category Protein Prices $419.00 Sizes 50 µg Source E.coli Species Human

FGB fusion protein - Ag10205 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

FGB fusion protein - ag10169 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Fibrinopeptide B - 350175 from ABBIOTEC Category Peptide Prices $71.00 Sizes 1 mg

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