| Gene Symbol |
UBE2G1
|
| Entrez Gene |
7326
|
| Alt Symbol |
E217K, UBC7, UBE2G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2G 1
|
| Other Description |
ubiquitin carrier protein G1|ubiquitin-conjugating enzyme E2 G1|ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)|ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)|ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)|ubiquitin-protein ligase G1
|
| Swissprots |
Q99462 P62253 D3DTK0 B2R7P2
|
| Accessions |
CAH05704 CAR82353 EAW90441 EAW90442 EAW90443 EAW90444 EAW90445 EAW90446 P62253 AI493944 AK313059 BAG35889 BC002775 AAH02775 BC017006 BC026288 AAH26288 BG703127 BI601205 BT007416 AAP36084 BT008255 AAP36947 BU161770 CD250951 D78514 BAA11410 NM_003342 NP_003333 NM_182682
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:20061386}.
|
| Tissue Specificity |
Widely expressed, mainly in skeletal muscle. {ECO:0000269|PubMed:8893823}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|