Gene Symbol | UBE2G1 |
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Entrez Gene | 7326 |
Alt Symbol | E217K, UBC7, UBE2G |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin-conjugating enzyme E2G 1 |
Other Description | ubiquitin carrier protein G1|ubiquitin-conjugating enzyme E2 G1|ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)|ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)|ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)|ubiquitin-protein ligase G1 |
Swissprots | Q99462 P62253 D3DTK0 B2R7P2 |
Accessions | CAH05704 CAR82353 EAW90441 EAW90442 EAW90443 EAW90444 EAW90445 EAW90446 P62253 AI493944 AK313059 BAG35889 BC002775 AAH02775 BC017006 BC026288 AAH26288 BG703127 BI601205 BT007416 AAP36084 BT008255 AAP36947 BU161770 CD250951 D78514 BAA11410 NM_003342 NP_003333 NM_182682 |
Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:20061386}. |
Tissue Specificity | Widely expressed, mainly in skeletal muscle. {ECO:0000269|PubMed:8893823}. |
Top Pathways | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |
UBE2G1 CRISPR/Cas9 KO Plasmid (h) - sc-416995 from Santa Cruz Biotechnology
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UBE2G1 HDR Plasmid (h) - sc-416995-HDR from Santa Cruz Biotechnology
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UBE2G1 Double Nickase Plasmid (h) - sc-416995-NIC from Santa Cruz Biotechnology
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UBE2G1 Double Nickase Plasmid (h2) - sc-416995-NIC-2 from Santa Cruz Biotechnology
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UBE2G1 CRISPR Activation Plasmid (h) - sc-416995-ACT from Santa Cruz Biotechnology
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UBE2G1 CRISPR Activation Plasmid (h2) - sc-416995-ACT-2 from Santa Cruz Biotechnology
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UBE2G1 Lentiviral Activation Particles (h) - sc-416995-LAC from Santa Cruz Biotechnology
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UBE2G1 Lentiviral Activation Particles (h2) - sc-416995-LAC-2 from Santa Cruz Biotechnology
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UBE2G1 siRNA (h) - sc-93745 from Santa Cruz Biotechnology
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UBE2G1 shRNA Plasmid (h) - sc-93745-SH from Santa Cruz Biotechnology
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UBE2G1 shRNA (h) Lentiviral Particles - sc-93745-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU015111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22365 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22365 from Sigma-Aldrich
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UBE2G1 siRNA (Human) - CRH5009 from Cohesion Biosciences
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UBE2G1 RNAi - H00007326-R01 from Novus Biologicals
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UBE2G1 - MBS827858 from MyBioSource
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shRNA set against Human UBE2G1 (NM_003342.4) - SHH438976 from Creative biogene
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shRNA set against Human UBE2G1(NM_003342.4) - SHL110854 from Creative biogene
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Human UBE2G1 siRNA - orb265511 from Biorbyt
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UBE2G1 shRNA Plasmid (Human) - CHH5009 from Cohesion Biosciences
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UBE2G1 miRNA 3'UTR clone - MiUTR1H-10948 from Creative biogene
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