| Gene Symbol |
PDIA6
|
| Entrez Gene |
10130
|
| Alt Symbol |
ERP5, P5, TXNDC7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein disulfide isomerase family A, member 6
|
| Other Description |
ER protein 5|endoplasmic reticulum protein 5|protein disulfide isomerase P5|protein disulfide isomerase-associated 6|protein disulfide isomerase-related protein|protein disulfide-isomerase A6|thioredoxin domain containing 7 (protein disulfide isomerase)|thioredoxin domain-containing protein 7
|
| Swissprots |
Q6ZSH5 F8WA83 Q15084 B5MCQ5 Q53RC7 Q99778 B3KY95 B7Z254 B7Z4M8
|
| Accessions |
AAY24070 EAX00949 EAX00950 Q15084 AK125449 AK127433 BAC86977 AK131234 BAG54757 AK225496 AK289428 BAF82117 AK294347 BAH11740 AK297547 BAH12614 BC001312 AAH01312 BF979486 BM511594 D49489 BAA08450 DA976962 DQ891186 ABM82112 DQ894369 ABM85295 HY166449 U79278 AAB50217 XM_011510308 XP_011508610 NM_001282704 NP_001269633 NM_001282705 NP_001269634 NM_001282706 NP_001269635 NM_001282707 NP_001269636 NM_005742 NP_005733
|
| Function |
May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. {ECO:0000269|PubMed:12204115, ECO:0000269|PubMed:15466936}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Tissue Specificity |
Expressed in platelets (at protein level). {ECO:0000269|PubMed:15466936}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|
![Western Blot: PDIA6 Overexpression Lysate (Adult Normal) [NBL1-14246] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDIA6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5489_PDIA6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14246-img0002.jpg)