| Gene Symbol |
TCF7L1
|
| Entrez Gene |
83439
|
| Alt Symbol |
TCF-3, TCF3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 7-like 1 (T-cell specific, HMG-box)
|
| Other Description |
HMG box transcription factor 3|transcription factor 7-like 1
|
| Swissprots |
Q9NP00 Q53R97 Q6PD70 Q9HCS4
|
| Accessions |
AAY15068 AAY24094 CAB91064 EAW99542 Q9HCS4 AB031046 BAB18185 BC058894 AAH58894 BF434361 XM_006712109 XP_006712172 NM_031283 NP_112573
|
| Function |
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. {ECO:0000269|PubMed:9916915}.
|
| Top Pathways |
Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer
|