TCF7L1

Gene Symbol TCF7L1
Entrez Gene 83439
Alt Symbol TCF-3, TCF3
Species Human
Gene Type protein-coding
Description transcription factor 7-like 1 (T-cell specific, HMG-box)
Other Description HMG box transcription factor 3|transcription factor 7-like 1
Swissprots Q9NP00 Q53R97 Q6PD70 Q9HCS4
Accessions AAY15068 AAY24094 CAB91064 EAW99542 Q9HCS4 AB031046 BAB18185 BC058894 AAH58894 BF434361 XM_006712109 XP_006712172 NM_031283 NP_112573
Function Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.
Subcellular Location Nucleus.
Tissue Specificity Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. {ECO:0000269|PubMed:9916915}.
Top Pathways Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer

TCF3/TCF7L1 (D15G11) Rabbit mAb - 2883 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D15G11
Western blot analysis of total lysates from various cell lines using TCF3/TCF7L1 (D15G11) Rabbit mAb.

TCF-3 (M-20) - sc-8635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TCF-3 (M-20): sc-8635. Western blot analysis of TCF-3 expression in non-transfected: sc-117752 (A) and human TCF-3 transfected: sc-116647 (B) 293T whole cell lysates.

TCF-3 (V-17) - sc-12491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TCF-3 (V-17): sc-12491. Western blot analysis of TCF-3 expression in non-transfected: sc-117752 (A) and human TCF-3 transfected: sc-116647 (B) 293T whole cell lysates.

TCF-3 (E-2) - sc-166411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TCF-3 (E-2): sc-166411. Western blot analysis of TCF-3 expression in A-431 (A) and HUV-EC-C (B) whole cell lysates.

Anti-TCF7L1 antibody - ab86175 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TCF7L1 antibody (ab86175) at 1 µg/ml (5% skim milk/ PBS buffer) + 293T cell lysate at 10 µg with gel concentration: 12%SecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TCF7L1 antibody - ab138173 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TCF7L1 antibody (ab138173) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-TCF7L1 antibody - ab82690 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TCF7L1 antibody (ab82690) at 1 µg/ml + 293T cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TCF7L1 antibody [EPR2031] - ab133360 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2031
All lanes : Anti-TCF7L1 antibody [EPR2031] (ab133360) at 1/1000 dilutionLane 1 : A431 lysateLane 2 : Human fetal small intestine lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TCF7L1 antibody [MM0931-17J17] - ab201599 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0931-17J17

Anti-TCF3/4 Antibody (aa31-331, clone 6F 12-3) - LS-C26584 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot of anti-TCF-3/4 clone 6F12-3 antibody at 4 ug/ml on Cos-1 cell control lysates (1) and Cos-1 cell lysates transfected with human TCF-3.

Anti-TCF7L1 / TCF-3 Antibody (aa429-581) - LS-C132609 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-TCF7L1 / TCF-3 Antibody (aa321-370) - LS-C291429 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TCF7L1 / TCF-3 Antibody (aa303-352) - LS-C200770 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using TCF7L1 antibody.

Anti-TCF7L1 / TCF-3 Antibody (aa70-98) - LS-C203898 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TCF7L1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The TCF7L1 antibody detected the TCF7L1 protein (arrow).

Anti-TCF7L1 / TCF-3 Antibody (aa72-121) - LS-C82001 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TCF7L1 / TCF-3 Antibody (C-Terminus) - LS-C345344 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TF7L1 Antibody with human Lung Tumor lysate.

Anti-TCF7L1 Antibody (Internal, clone EPR2031) - LS-C105549 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2031
Western blot analysis on (A) A431 and (B) fetal small intestine lysates using anti-TCF-3 antibody (LS-C105549), dilution 1:2000.

Anti-TCF7L1 / TCF-3 Antibody (aa35-84) IHC-plus™ - LS-B3476 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TCF7L1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3476 concentration 5 ug/ml.

TCF7L1/TCF3 Antibody - AF6116 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of human pancreas and human lung tissue. PVDF Membrane was probed with 0.2 µg/mL of Human TCF7L1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6116) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for TCF7L1 at approximately 70 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

TCF7L1/TCF3 Antibody (622782) - MAB61161 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 622782

TCF7L1/TCF3 Antibody (622722) - MAB6116 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 622722
Western blot shows lysates of human lung tissue, human pancreas tissue, and human spleen tissue. PVDF Membrane was probed with 1 µg/mL of Mouse Anti-Human TCF7L1/TCF3 Monoclonal Antibody (Catalog # MAB6116) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for TCF7L1 at approximately 75 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

TCF-3/E2A [p Thr355] Antibody - NB100-394 from Novus Biologicals

Prices $449.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TCF-3/E2A [p Thr355] Antibody [NB100-394] - Whole cell lysate from 293T cells that were transfected with an expression construct that encoded wild-type E2A (E47) or S352A/T355A/S359A mutant E2A (Mm). Antibody used at 0.1 ug/ml.

TCF7L2 Antibody (6F12-3) - NB110-10889 from Novus Biologicals

Prices $279.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal
Clone 6F12-3

TCF-3/E2A Antibody (6B8) - NBP1-42566 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6B8
Western Blot: TCF-3/E2A Antibody (6B8) [NBP1-42566] - Analysis using TCF3 mouse mAb against A549 (1), A431 (2), Hela (3), PANC-1 (4) and PC-3 (5) cell lysate.

TCF7L1/TCF3 Antibody - H00083439-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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