TCF7L1

Gene Symbol	TCF7L1
Entrez Gene	83439
Alt Symbol	TCF-3, TCF3
Species	Human
Gene Type	protein-coding
Description	transcription factor 7-like 1 (T-cell specific, HMG-box)
Other Description	HMG box transcription factor 3|transcription factor 7-like 1
Swissprots	Q9NP00 Q53R97 Q6PD70 Q9HCS4
Accessions	AAY15068 AAY24094 CAB91064 EAW99542 Q9HCS4 AB031046 BAB18185 BC058894 AAH58894 BF434361 XM_006712109 XP_006712172 NM_031283 NP_112573
Function	Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.
Subcellular Location	Nucleus.
Tissue Specificity	Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. {ECO:0000269|PubMed:9916915}.
Top Pathways	Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TCF-3 CRISPR/Cas9 KO Plasmid (h) - sc-400821 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 HDR Plasmid (h) - sc-400821-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 Double Nickase Plasmid (h) - sc-400821-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 Double Nickase Plasmid (h2) - sc-400821-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 CRISPR Activation Plasmid (h) - sc-400821-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 CRISPR Activation Plasmid (h2) - sc-400821-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 Lentiviral Activation Particles (h) - sc-400821-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 Lentiviral Activation Particles (h2) - sc-400821-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 siRNA (h) - sc-36618 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TCF-3 shRNA Plasmid (h) - sc-36618-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TCF-3 shRNA (h) Lentiviral Particles - sc-36618-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TCF7L1/TCF3 RNAi - H00083439-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TCF-3/E2A RNAi - H00006929-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU154451 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21149 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21149 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07244 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07244

TCF7L1 siRNA (Human) - CRJ3094 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TCF7L1 - MBS8217068 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TCF-3 CRISPR/Cas9 KO Plasmid (h2) - sc-400821-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TCF-3 HDR Plasmid (h2) - sc-400821-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human TCF7L1 (NM_031283.2) - SHH424868 from Creative biogene Category siRNA Species Reactivities Human

Human TCF7L1 siRNA - orb273595 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TCF7L1 shRNA Plasmid (Human) - CHJ3094 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TCF7L1 miRNA 3'UTR clone - MiUTR3H-06982 from Creative biogene Species Reactivities Human

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