POLR2A

Gene Symbol	POLR2A
Entrez Gene	5430
Alt Symbol	POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Other Description	DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit|DNA-directed RNA polymerase II subunit A|DNA-directed RNA polymerase II subunit RPB1|DNA-directed RNA polymerase III largest subunit|RNA polymerase II subunit B1|RNA-directed RNA polymerase II subunit RPB1
Swissprots	A6NN93 Q6NX41 B9EH88 P24928
Accessions	CAA52862 EAW90181 EAW90182 EAW90183 P24928 AK293777 BAG57192 AK304882 BAG65619 AW589665 BC067295 AAH67295 BC107140 BC137231 AAI37232 BQ353795 BQ891728 BU730469 BU739765 CV355924 DA923649 M21610 AAA60135 X63564 CAA45125 NM_000937 NP_000928
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA h
Subcellular Location	Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways	Huntington's disease, Herpes simplex infection, Epstein-Barr virus infection, Purine metabolism, RNA polymerase

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNA polymerase II CTD repeat YSPTSPS (phospho S5) peptide - ab18488 from Abcam Category Peptide

Human RNA polymerase II CTD repeat YSPTSPS peptide - ab17564 from Abcam Category Peptide

Human RNA polymerase II CTD repeat YSPTSPS protein fragment - ab81834 from Abcam Category Protein Source E. coli Species Human

Human RNA polymerase II CTD repeat YSPTSPS protein fragment - ab81888 from Abcam Category Protein Source E. coli Species Human

S. cerevisiae RNA polymerase II CTD repeat YSPTSPS (phospho S2) peptide - ab12793 from Abcam Category Peptide

S. cerevisiae RNA polymerase II CTD repeat YSPTSPS peptide - ab12795 from Abcam Category Peptide

POLR2A / RNA polymerase II Antibody Blocking Peptide - LS-E22660 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNA Polymerase II/POLR2A Protein - H00005430-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human POLR2A - POLR2A-1148H from Creative Biomart Category Protein Source HeLa cells.

Recombinant Human POLR2A, CT Domain - POLR2A-1149H from Creative Biomart Category Protein Source E. coli.

Recombinant Human POLR2A, CT Domain, His-tagged - POLR2A-2513H from Creative Biomart Category Protein Source E. coli.

Recombinant Human POLR2A, His-tagged - POLR2A-29986TH from Creative Biomart Category Protein Source E. coli

Recombinant Human POLR2A - POLR2A-30767TH from Creative Biomart Category Protein Source E. coli

Recombinant Human POLR2A, His-tagged - POLR2A-8461H from Creative Biomart Category Protein Source E. coli Species Human

Rpb1 CTD (pSer5) Blocking Peptide - CBP3292 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Zebrafish

Rpb1 (P1613) Peptide - BS1419P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Rpb1 (S1619) Peptide - BS4246P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant DNA-directed RNA polymerase II subunit RPB1(RPB1) - CSB-YP018327EPO CSB-EP018327EPO CSB-BP018327EPO CSB-MP018327EPO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

Recombinant Human DNA-directed RNA polymerase II subunit RPB1(POLR2A) ,partial - CSB-YP018327HU CSB-EP018327HU CSB-BP018327HU CSB-MP018327HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNA Polymerase II/POLR2A Recombinant Protein Antigen - NBP1-87785PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR2A-Antibody-N-term-Blocking-Peptide - BP6821a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLR2A Peptide, Human - M34GP12089H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rpb1 CTD Blocking Peptide - CBP7055 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Dog, Monkey, Zebrafish

Native Human POLR2A Active - CSI14614 from Cell Science Prices $1,230.00 Sizes 2 μg Species Human

Recombinant Human POLR2A Active - CSI13889 from Cell Science Prices $740.00 Sizes 10 μg Species Human

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