GEMIN2

Gene Symbol	GEMIN2
Entrez Gene	8487
Alt Symbol	SIP1, SIP1-delta
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 2
Other Description	SMN interacting protein 1-delta|component of gems 2|gem-associated protein 2|gemin-2|survival of motor neuron protein interacting protein 1
Swissprots	O14893 B2R9W8 Q9NS78 Q9NS77 Q9NS79 Q2M3B3 Q9H4F5
Accessions	CAC16117 CAC16171 EAW65825 EAW65826 EAW65827 EAW65828 EAW65829 EAW65830 O14893 AB037701 BAB03508 AB037702 BAB03509 AB037703 BAB03510 AF027150 AAB82297 AK313947 BAG36665 BC028095 BC104968 AAI04969 CN484054 XM_011537238 XP_011535540 NM_001009182 NP_001009182 NM_001009183 NP_001009183 NM_003616 NP_003607
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:9323129}.
Subcellular Location	Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIP1 293T Cell Transient Overexpression Lysate(Denatured) - H00008487-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GEMIN2 overexpression lysate - LY418547 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN2 overexpression lysate - LY422905 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GEMIN2 overexpression lysate - LY425269 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIP1 293 Cell Lysate - 408654 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

GEMIN2 Overexpression Lysate (Denatured) - H00008487-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

GEMIN2 Overexpression Lysate (Native) - NBL1-15969 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIP1 Over-expression Lysate Product - GWB-1F4B3C from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human GEMIN2 Knockdown Stable Cell Line - CSC-DC006204 from Creative biogene Category Cell Line Species Human

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