GEMIN2
| Gene Symbol | GEMIN2 |
|---|---|
| Entrez Gene | 8487 |
| Alt Symbol | SIP1, SIP1-delta |
| Species | Human |
| Gene Type | protein-coding |
| Description | gem (nuclear organelle) associated protein 2 |
| Other Description | SMN interacting protein 1-delta|component of gems 2|gem-associated protein 2|gemin-2|survival of motor neuron protein interacting protein 1 |
| Swissprots | O14893 B2R9W8 Q9NS78 Q9NS77 Q9NS79 Q2M3B3 Q9H4F5 |
| Accessions | CAC16117 CAC16171 EAW65825 EAW65826 EAW65827 EAW65828 EAW65829 EAW65830 O14893 AB037701 BAB03508 AB037702 BAB03509 AB037703 BAB03510 AF027150 AAB82297 AK313947 BAG36665 BC028095 BC104968 AAI04969 CN484054 XM_011537238 XP_011535540 NM_001009182 NP_001009182 NM_001009183 NP_001009183 NM_003616 NP_003607 |
| Function | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:9323129}. |
| Subcellular Location | Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm. |
| Top Pathways | RNA transport |
Gemin2 CRISPR/Cas9 KO Plasmid (h) - sc-403867 from Santa Cruz Biotechnology
|
||||||||
Gemin2 HDR Plasmid (h) - sc-403867-HDR from Santa Cruz Biotechnology
|
||||||||
Gemin2 Double Nickase Plasmid (h) - sc-403867-NIC from Santa Cruz Biotechnology
|
||||||||
Gemin2 Double Nickase Plasmid (h2) - sc-403867-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Gemin2 CRISPR Activation Plasmid (h) - sc-403867-ACT from Santa Cruz Biotechnology
|
||||||||
Gemin2 CRISPR Activation Plasmid (h2) - sc-403867-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Gemin2 Lentiviral Activation Particles (h) - sc-403867-LAC from Santa Cruz Biotechnology
|
||||||||
Gemin2 Lentiviral Activation Particles (h2) - sc-403867-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Gemin2 siRNA (h) - sc-42129 from Santa Cruz Biotechnology
|
||||||||
Gemin2 shRNA Plasmid (h) - sc-42129-SH from Santa Cruz Biotechnology
|
||||||||
Gemin2 shRNA (h) Lentiviral Particles - sc-42129-V from Santa Cruz Biotechnology
|
||||||||
GEMIN2 RNAi - H00008487-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU098501 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN19349 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19349 from Sigma-Aldrich
|
||||||||
GEMIN2 siRNA (Human) - CRH5564 from Cohesion Biosciences
|
||||||||
SIP1 RNAi - H00008487-R03 from Novus Biologicals
|
||||||||
GEMIN2 RNAi - H00008487-R01 from Novus Biologicals
|
||||||||
GEMIN2 - MBS8217989 from MyBioSource
|
||||||||
shRNA set against Human SIP1 (NM_003616.2) - SHH407632 from Creative biogene
|
||||||||
shRNA set against Human SIP1(NM_001009183.1) - SHH221504 from Creative biogene
|
||||||||
shRNA set against Human SIP1(NM_001009182.1) - SHH221522 from Creative biogene
|
||||||||
shRNA set against Human SIP1(NM_003616.2) - SHH221540 from Creative biogene
|
||||||||
GEMIN2 shRNA Plasmid (Human) - CHH5564 from Cohesion Biosciences
|
||||||||
GEMIN2 miRNA 3'UTR clone - MiUTR1H-09402 from Creative biogene
|