GEMIN2

Gene Symbol	GEMIN2
Entrez Gene	8487
Alt Symbol	SIP1, SIP1-delta
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 2
Other Description	SMN interacting protein 1-delta|component of gems 2|gem-associated protein 2|gemin-2|survival of motor neuron protein interacting protein 1
Swissprots	O14893 B2R9W8 Q9NS78 Q9NS77 Q9NS79 Q2M3B3 Q9H4F5
Accessions	CAC16117 CAC16171 EAW65825 EAW65826 EAW65827 EAW65828 EAW65829 EAW65830 O14893 AB037701 BAB03508 AB037702 BAB03509 AB037703 BAB03510 AF027150 AAB82297 AK313947 BAG36665 BC028095 BC104968 AAI04969 CN484054 XM_011537238 XP_011535540 NM_001009182 NP_001009182 NM_001009183 NP_001009183 NM_003616 NP_003607
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:9323129}.
Subcellular Location	Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Gemin 2 full length protein - ab152878 from Abcam Category Protein Source Wheat germ Species Human

SIP1 Recombinant Protein - H00008487-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GEMIN2 Blocking Peptide - NBP1-77177PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Gemin2 Blocking Peptide - abx064220 from Abbexa Category Peptide Species Human, Mouse, Rat

SIP1 / GEMIN2 - H00008487-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SIP1 / GEMIN2 - H00008487-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SIP1 / GEMIN2 control peptide - AP26221CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SIP1 Peptide - 5823P from ProSci Category Peptide Species Human

SIP1 fusion protein - Ag16500 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SIP1 fusion protein - ag18073 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Gemin2 Blocking Peptide - CBP3026 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Gem-associated protein 2(GEMIN2) - CSB-YP021329HU CSB-EP021329HU CSB-BP021329HU CSB-MP021329HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SIP1 Protein - abx165005 from Abbexa Category Protein Species Human, Mouse, Rat

SIP1 / GEMIN2 (transcript variant alpha) - TP311219 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GEMIN2 Recombinant Protein Antigen - NBP2-38553PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SIP1-Blocking-Peptide-C-term - BP20725c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GEMIN2 Peptide, Human - M34GP06204H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gem-associated protein 2 (GEMIN2), Recombinant Protein - MBS1016508 from MyBioSource Category Protein Prices $1,035.00, $1,035.00, $1,265.00, $1,265.00, $1,600.00, $1,600.00, $2,065.00, $2,065.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GEMIN2 Recombinant Protein Antigen - NBP2-55393PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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