MST1R

Gene Symbol MST1R
Entrez Gene 4486
Alt Symbol CD136, CDw136, PTK8, RON
Species Human
Gene Type protein-coding
Description macrophage stimulating 1 receptor
Other Description MSP receptor|MST1R variant RON30|MST1R variant RON62|PTK8 protein tyrosine kinase 8|RON variant 21|RON variant E2E3|c-met-related tyrosine kinase|macrophage stimulating 1 receptor (c-met-related tyrosine kinase)|macrophage-stimulating protein receptor|p185-Ron|soluble RON variant 1|soluble RON variant 2|soluble RON variant 3|soluble RON variant 4
Swissprots B5A946 B5A945 B5A947 B5A944 Q04912
Accessions EAW65036 Q04912 AK303234 BAG64320 BP288515 BU542597 CA503122 EU826582 ACF47618 EU826583 ACF47619 EU826584 ACF47620 EU826585 ACF47621 HQ908652 AEB22138 JN689381 AEY68264 JN689382 AEY68265 JN983806 AEW68340 X70040 CAA49634 XM_005265170 XP_005265227 XM_011533739 XP_011532041 XM_011533740 XP_011532042 XM_011533741 XP_011532043 XM_011533742 XP_011532044 XM_011533743 XP_011532045 XM_011533744 XP_011532046 XM_011533745 XP_011532047 XR_245136 XR_940428 NM_001244937 NP_001231866 NM_002447 NP_002438
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in respon
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in colon, skin, lung and bone marrow. {ECO:0000269|PubMed:8062829}.

Ron (1B5) Mouse mAb - 4269 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 1B5
Western blot analysis of extracts from various cell types using Ron (1B5) Mouse mAb.

Ron (C81H9) Rabbit mAb - 2654 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C81H9
Western blot analysis of BxPC-3 cell extracts using Ron (C81H9) Rabbit mAb.

Ron α (A-15) - sc-14628 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ron α (A-15): sc-14628. Western blot analysis of Ron α expression in RAW 264.7 whole cell lysate.

Ron α (H-170) - sc-20740 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Ron α (29) - sc-136060 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Ron α (29): sc-136060. Western blot analysis of Ron α expression in MDCK whole cell lysate.

Ron β (E-3) - sc-74588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ron β (E-3): sc-74588. Western blot analysis of Ron β expression in HCT 116 whole cell lysate.

Ron β (E-20) - sc-27114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ron β (C-20) - sc-322 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ron β (C-20): sc-322. Western blot analysis of Ron β expression in NIH/3T3 cells transfected with cDNA encoding a truncated human Ron β protein. Cells kindly provided by D. Bottaro.

Ron β (A-8) - sc-74587 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ron β (A-8): sc-74587. Western blot analysis of Ron β expression in SW480 (A) and T-47D (B) whole cell lysates.

Ron β (H-160) - sc-25781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ron β (H-160): sc-25781. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of macrophages.

Ron β (G-20) - sc-27112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Ron β (Tyr 1238/ Tyr 1239) - sc-16838 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Ron β (Tyr 1238/Tyr 1239)-R: sc-16838-R. Western blot analysis of Ron β phosphorylation in untreated (A) and lambda protein phosphatase treated (B) HeLa whole cell lysates.

p-Ron β (Tyr 1353) - sc-16839 from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Goat
Clonality Polyclonal
p-Ron β (Tyr 1353)-R: sc-16839-R. Western blot analysis of Ron β phosphorylation in untreated (A), pervanadate treated (B) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C) A-431 whole cell lysates.

p-Ron β (Tyr 1360) - sc-16840 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-Ron β (Tyr 1360)-R: sc-16840-R. Western blot analysis of Ron β phosphorylation in untreated (A), pervanadate treated (B) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C) A-431 whole cell lysates.

Anti-RON (phospho S1394) antibody - ab61007 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RON (phospho S1394) antibody (ab61007) at 1/500 dilutionLane 1 : extracts from HeLa cells, treated with TNF-a (20ng/ml, 2mins)Lane 2 : extracts from HeLa cells, treated with TNF-a (20ng/ml, 2mins) with immunizing phosphopeptide

Anti-RON (phospho Y1238 + Y1239) antibody - ab125264 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RON (phospho Y1238 + Y1239) antibody (ab125264) at 1/500 dilutionLane 1 : Cell lysate from MSP-treated RON transfected HEK293 Lane 2 : Cell lysate from MSP-treated RON transfected HEK293 with immunizing peptide

Anti-RON (phospho Y1238) antibody - ab125291 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Dot Blot: 1 µg peptide was blotted onto NC membrane. 1: RON (pY1238/Y1239). 2: RON (Y1238). 3: RON (Y1239). 4: RON (Nonphospho). 5: Non-related Phosphopeptide. ab125291 used at a dilution of 1/2000.

Anti-RON (phospho Y1238) antibody - ab203752 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin embedded rat brain tissue labeling RON (phospho Y1238) using ab203752 at 1/200 dilution, followed by secondary detection and DAB staining.

Anti-RON (phospho Y1239) antibody - ab125252 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Dot Blot: 1 mg peptide was blot onto NC membrane A: CD136 (pY1238/Y1239) B: CD136(pY1238) C: CD136 (pY1239 - ab125252) D: CD136 (Non phospho) E: Non related Phosphopeptide) were blotted at a 1/2000 dilution by: 1: Rabbit anti-CD136 (pY1238/Y1239) 2: Rabbit anti-CD136 (pY1238) 3: Rabbit anti-CD136 (pY1239 - ab125252) 4: Rabbit anti-CD136

Anti-RON (phospho Y1353) antibody [EPR5598] - ab124671 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5598
All lanes : Anti-RON (phospho Y1353) antibody [EPR5598] (ab124671) at 1/50000 dilutionLane 1 : A431 cell lysates, untreatedLane 2 : A431 cell lysates, treated with pervanadate

Anti-RON antibody - ab125283 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RON antibody (ab125283) at 1/500 dilutionLane 1 : MSP-treated RON-transfected HEK293 cell lysateLane 2 : MSP-treated RON-transfected HEK293 cell lysate with immunizing peptide

Anti-RON antibody - ab70936 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RON antibody (ab70936) at 1/100 dilution + THP1 cell lysate at 12.5 µgSecondaryHRP-anti-rabbitdeveloped using the ECL technique

Anti-RON antibody - ab93129 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RON antibody (ab93129) at 1/100 dilution + HL-60 cell line lysates at 35 µg

Anti-RON antibody - ab85063 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human stomach tissue using 1/200 ab85063. Note membrane staining.

Anti-RON antibody [1B5A9] - ab76360 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1B5A9
All lanes : Anti-RON antibody [1B5A9] (ab76360) at 1/2000 dilutionLane 1 : Cell lysates prepared from HCC827 cellsLane 2 : Cell lysates prepared from HT-29 cellsLane 3 : Cell lysates prepared from HCT-116 cellsLane 4 : Cell lysates prepared from BxPC-3 cellsLysates/proteins at 100 µg per lane.SecondaryHRP-conjugated Goat polyclonal to mouse IgG1
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