MST1R

Gene Symbol	MST1R
Entrez Gene	4486
Alt Symbol	CD136, CDw136, PTK8, RON
Species	Human
Gene Type	protein-coding
Description	macrophage stimulating 1 receptor
Other Description	MSP receptor|MST1R variant RON30|MST1R variant RON62|PTK8 protein tyrosine kinase 8|RON variant 21|RON variant E2E3|c-met-related tyrosine kinase|macrophage stimulating 1 receptor (c-met-related tyrosine kinase)|macrophage-stimulating protein receptor|p185-Ron|soluble RON variant 1|soluble RON variant 2|soluble RON variant 3|soluble RON variant 4
Swissprots	B5A946 B5A945 B5A947 B5A944 Q04912
Accessions	EAW65036 Q04912 AK303234 BAG64320 BP288515 BU542597 CA503122 EU826582 ACF47618 EU826583 ACF47619 EU826584 ACF47620 EU826585 ACF47621 HQ908652 AEB22138 JN689381 AEY68264 JN689382 AEY68265 JN983806 AEW68340 X70040 CAA49634 XM_005265170 XP_005265227 XM_011533739 XP_011532041 XM_011533740 XP_011532042 XM_011533741 XP_011532043 XM_011533742 XP_011532044 XM_011533743 XP_011532045 XM_011533744 XP_011532046 XM_011533745 XP_011532047 XR_245136 XR_940428 NM_001244937 NP_001231866 NM_002447 NP_002438
Function	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in respon
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in colon, skin, lung and bone marrow. {ECO:0000269|PubMed:8062829}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RON protein fragment - ab70541 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human RON protein fragment - ab152542 from Abcam Category Protein Source Wheat germ Species Human

MST1R / RON Antibody Blocking Peptide - LS-E3006 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MST1R / RON Antibody Blocking Peptide - LS-E9181 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MST1R / RON Antibody Blocking Peptide - LS-E29236 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MST1R / RON Antibody Blocking Peptide - LS-E29238 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MST1R / RON Antibody Blocking Peptide - LS-E29239 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MST1R / RON Antibody Blocking Peptide - LS-E29237 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human MSP R/Ron Protein - H00004486-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RON-Antibody-Blocking-peptide - BP7674c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human MSP R/Ron, CF - 1947-MS-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu25-Leu571 (single chain) & Gly310-Leu571 (beta), with a C-terminal 10-His tag; Glu25-Arg309 (alpha)

Human CD136 protein - orb84330 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human MST1R Protein - abx067906 from Abbexa Category Protein Source E.coli Species Human

CD136 / MST1R - H00004486-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD136 / MST1R - H00004486-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD136 / MST1R - P5634 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

Recombinant Human MST1R, His tagged - MST1R-3917H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human MST1R - MST1R-30956TH from Creative Biomart Category Protein

Recombinant Human MST1R, GST-tagged, Active - MST1R-422H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Macrophage Stimulating 1 Receptor (MST1R) - RPB525Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Macrophage Stimulating 1 Receptor (MST1R) - RPB525Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Human CD136 / MST1R Protein (His Tag) - 11608-H08H-50 from Sino Biological Category Protein Source Human Cells Species Human

Ron Protein, active, 10 µg - 14-581 from EMD Millipore Category Protein Prices $401.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source expressed by baculovirus in Sf21 insect cells

Recombinant Macrophage Stimulating 1 Receptor (MST1R) - RPB525Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Macrophage-stimulating protein receptor(MST1R) ,partial - CSB-YP015056HU CSB-EP015056HU CSB-BP015056HU CSB-MP015056HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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