| Gene Symbol |
MST1R
|
| Entrez Gene |
4486
|
| Alt Symbol |
CD136, CDw136, PTK8, RON
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
macrophage stimulating 1 receptor
|
| Other Description |
MSP receptor|MST1R variant RON30|MST1R variant RON62|PTK8 protein tyrosine kinase 8|RON variant 21|RON variant E2E3|c-met-related tyrosine kinase|macrophage stimulating 1 receptor (c-met-related tyrosine kinase)|macrophage-stimulating protein receptor|p185-Ron|soluble RON variant 1|soluble RON variant 2|soluble RON variant 3|soluble RON variant 4
|
| Swissprots |
B5A946 B5A945 B5A947 B5A944 Q04912
|
| Accessions |
EAW65036 Q04912 AK303234 BAG64320 BP288515 BU542597 CA503122 EU826582 ACF47618 EU826583 ACF47619 EU826584 ACF47620 EU826585 ACF47621 HQ908652 AEB22138 JN689381 AEY68264 JN689382 AEY68265 JN983806 AEW68340 X70040 CAA49634 XM_005265170 XP_005265227 XM_011533739 XP_011532041 XM_011533740 XP_011532042 XM_011533741 XP_011532043 XM_011533742 XP_011532044 XM_011533743 XP_011532045 XM_011533744 XP_011532046 XM_011533745 XP_011532047 XR_245136 XR_940428 NM_001244937 NP_001231866 NM_002447 NP_002438
|
| Function |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in respon
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in colon, skin, lung and bone marrow. {ECO:0000269|PubMed:8062829}.
|