VPS36

Gene Symbol VPS36
Entrez Gene 51028
Alt Symbol C13orf9, CGI-145, EAP45
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 36 homolog (S. cerevisiae)
Other Description ELL-associated protein of 45 kDa|ESCRT-II complex subunit VPS36|vacuolar protein-sorting-associated protein 36
Swissprots Q9H8Z5 Q5H9S1 Q3ZCV7 Q86VN1 Q9Y3E3 Q5VXB6 A8K125
Accessions EAW55895 Q86VN1 AB208956 BAD92193 AF151903 AAD34140 AI221133 AI352102 AK022911 AK023182 BAB14451 AK289740 BAF82429 BC037279 AAH37279 BC050439 AAH50439 BG400860 BX647847 CB959894 CR933653 CAI45953 DA461148 NM_001282168 NP_001269097 NM_001282169 NP_001269098 NM_016075 NP_057159
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. {ECO:0000269|PubMed:15755741}.
Subcellular Location Cytoplasm. Endosome. Late endosome. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways Endocytosis

Eap45 (T-20) - sc-79931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Eap45 (T-20): sc-79931. Western blot analysis of Eap45 expression in mouse embryo (A) and mouse ovary (B) tissue extracts.

Eap45 (K-18) - sc-79930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Eap45 (H-300) - sc-292231 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-VPS36 antibody - ab67801 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-VPS36 antibody (ab67801) at 1/500 dilutionLane 1 : VPS36 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-VPS36 Antibody (Internal) - LS-C95262 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-VPS36 Antibody (aa91-140) - LS-C146359 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
VPS36 antibody LS-C146359 Western blot of Mouse Liver lysate. Antibody concentration 1 ug/ml.

VPS36 Antibody - NBP2-13518 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VPS36 Antibody - NBP2-20877 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VPS36 Antibody - NBP2-13519 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: VPS36 Antibody [NBP2-13519] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

VPS36 Antibody - H00051028-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: VPS36 Antibody [H00051028-B01P] - Analysis of VPS36 expression in transfected 293T cell line by VPS36 polyclonal antibody. Lane 1: VPS36 transfected lysate(42.46 KDa). Lane 2: Non-transfected lysate.

Anti-VPS36 antibody produced in rabbit - HPA043947 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-VPS36:<B>Cat. No. HPA043947</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Anti-VPS36 antibody produced in mouse - SAB1407433 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-VPS36: <B>Cat. No. SAB1407433</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~42.5 kDa using VPS36 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-VPS36 antibody produced in rabbit - SAB2700536 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-VPS36: <B>Cat. No. SAB2700536</B>: Immunohistochemical analysis of paraffin-embedded DLD1 xenograft, using VPS36 antibody at 1:500 dilution.

Anti-VPS36 antibody produced in rabbit - HPA039734 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-VPS36:<B>Cat. No. HPA039734</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

VPS36 antibody - H00051028-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of VPS36 expression in transfected 293T cell line (H00051028-T01) by VPS36 MaxPab polyclonal antibody. Lane 1: VPS36 transfected lysate(42.46 KDa). Lane 2: Non-transfected lysate.

VPS36 antibody - 14262-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

VPS36 Antibody - 40296 from Signalway Antibody

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human Liver cancer tissue using #40296 at dilution 1/200.

Anti-VPS36 monoclonal antibody - DCABH-17385 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

Anti-VPS36 (aa 120-278) polyclonal antibody - DPABH-23750 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

VPS36 Polyclonal Antibody - PA5-30611 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of VPS36 in paraffin-embedded DLD-1 xenograft using a VPS36 polyclonal antibody (Product # PA5-30611) at a dilution of 1:100.

VPS36 - MBS270189 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: NT2D1 10% SDS PAGE diluted at 1:1000

VPS36, Polyclonal Antibody - MBS9407507 from MyBioSource

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

VPS36 Antibody - CSB-PA068002 from Cusabio

Host Rabbit

VPS36 Antibody - CSB-PA919719 from Cusabio

Host Rabbit

VPS36 Antibody - 43983 from Signalway Antibody

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Gel: 8%SDS-PAGE Lysate: 40 μg, Lane: Human tonsil tissue lysate, Primary antibody:VPS36 antibody at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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