VPS36

Gene Symbol VPS36
Entrez Gene 51028
Alt Symbol C13orf9, CGI-145, EAP45
Species Human
Gene Type protein-coding
Description vacuolar protein sorting 36 homolog (S. cerevisiae)
Other Description ELL-associated protein of 45 kDa|ESCRT-II complex subunit VPS36|vacuolar protein-sorting-associated protein 36
Swissprots Q9H8Z5 Q5H9S1 Q3ZCV7 Q86VN1 Q9Y3E3 Q5VXB6 A8K125
Accessions EAW55895 Q86VN1 AB208956 BAD92193 AF151903 AAD34140 AI221133 AI352102 AK022911 AK023182 BAB14451 AK289740 BAF82429 BC037279 AAH37279 BC050439 AAH50439 BG400860 BX647847 CB959894 CR933653 CAI45953 DA461148 NM_001282168 NP_001269097 NM_001282169 NP_001269098 NM_016075 NP_057159
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. {ECO:0000269|PubMed:15755741}.
Subcellular Location Cytoplasm. Endosome. Late endosome. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways Endocytosis

Eap45 CRISPR/Cas9 KO Plasmid (h) - sc-409919 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Eap45 HDR Plasmid (h) - sc-409919-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS36 Double Nickase Plasmid (h) - sc-409919-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Eap45 Double Nickase Plasmid (h2) - sc-409919-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS36 CRISPR Activation Plasmid (h) - sc-409919-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Eap45 CRISPR Activation Plasmid (h2) - sc-409919-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VPS36 Lentiviral Activation Particles (h) - sc-409919-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Eap45 Lentiviral Activation Particles (h2) - sc-409919-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Eap45 siRNA (h) - sc-77215 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Eap45 shRNA Plasmid (h) - sc-77215-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Eap45 shRNA (h) Lentiviral Particles - sc-77215-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU046421 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22720 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22720 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

VPS36 siRNA (Human) - CRH9468 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

VPS36 - MBS8236460 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human VPS36 (NM_016075.2) - SHH444964 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human VPS36(NM_016075.2) - SHL127710 from Creative biogene

Category siRNA
Species Reactivities Human

VPS36 shRNA Plasmid (Human) - CHH9468 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

VPS36 miRNA 3'UTR clone - MiUTR1H-11153 from Creative biogene

Species Reactivities Human
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