| Gene Symbol |
VPS36
|
| Entrez Gene |
51028
|
| Alt Symbol |
C13orf9, CGI-145, EAP45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 36 homolog (S. cerevisiae)
|
| Other Description |
ELL-associated protein of 45 kDa|ESCRT-II complex subunit VPS36|vacuolar protein-sorting-associated protein 36
|
| Swissprots |
Q9H8Z5 Q5H9S1 Q3ZCV7 Q86VN1 Q9Y3E3 Q5VXB6 A8K125
|
| Accessions |
EAW55895 Q86VN1 AB208956 BAD92193 AF151903 AAD34140 AI221133 AI352102 AK022911 AK023182 BAB14451 AK289740 BAF82429 BC037279 AAH37279 BC050439 AAH50439 BG400860 BX647847 CB959894 CR933653 CAI45953 DA461148 NM_001282168 NP_001269097 NM_001282169 NP_001269098 NM_016075 NP_057159
|
| Function |
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. {ECO:0000269|PubMed:15755741}.
|
| Subcellular Location |
Cytoplasm. Endosome. Late endosome. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
|
| Top Pathways |
Endocytosis
|