VPS36

Gene Symbol	VPS36
Entrez Gene	51028
Alt Symbol	C13orf9, CGI-145, EAP45
Species	Human
Gene Type	protein-coding
Description	vacuolar protein sorting 36 homolog (S. cerevisiae)
Other Description	ELL-associated protein of 45 kDa|ESCRT-II complex subunit VPS36|vacuolar protein-sorting-associated protein 36
Swissprots	Q9H8Z5 Q5H9S1 Q3ZCV7 Q86VN1 Q9Y3E3 Q5VXB6 A8K125
Accessions	EAW55895 Q86VN1 AB208956 BAD92193 AF151903 AAD34140 AI221133 AI352102 AK022911 AK023182 BAB14451 AK289740 BAF82429 BC037279 AAH37279 BC050439 AAH50439 BG400860 BX647847 CB959894 CR933653 CAI45953 DA461148 NM_001282168 NP_001269097 NM_001282169 NP_001269098 NM_016075 NP_057159
Function	Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. {ECO:0000269|PubMed:15755741}.
Subcellular Location	Cytoplasm. Endosome. Late endosome. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS36 full length protein - ab162398 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human VPS36 Protein - H00051028-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VPS36 - H00051028-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VPS36 - H00051028-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VPS36 fusion protein - Ag5549 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human VPS36, His-tagged - VPS36-3679H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Vacuolar protein-sorting-associated protein 36(VPS36) - CSB-YP801240HU CSB-EP801240HU CSB-BP801240HU CSB-MP801240HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

VPS36 - TP306006 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Vacuolar protein-sorting-associated protein 36 (VPS36) , Recombinant Protein - MBS1340696 from MyBioSource Category Protein Prices $1,845.00, $1,845.00, $2,310.00, $2,310.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

VPS36 Recombinant Protein Antigen - NBP2-13519PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

VPS36 Protein - NBP2-13518PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

VPS36 Peptide, Human - M34GP17317H from Creative Peptides Category Peptide Source Synthetic. Species Human

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