NLRP4

Gene Symbol NLRP4
Entrez Gene 147945
Alt Symbol CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
Species Human
Gene Type protein-coding
Description NLR family, pyrin domain containing 4
Other Description NACHT, LRR and PYD containing protein 4|NACHT, LRR and PYD domains-containing protein 4|NACHT, leucine rich repeat and PYD containing 4|PAAD and NACHT-containing protein 2|PYRIN and NACHT-containing protein 2|PYRIN-containing APAF1-like protein 4|cancer/testis antigen 58|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4|ribonuclease inhibitor 2
Swissprots Q96AY6 Q86W87 Q96MN2
Accessions EAW72417 EAW72418 Q96MN2 AF442488 AAL35293 AF479747 AAL87104 AF482706 AAL88672 AK056688 BAB71254 AK315003 BAG37498 AY072792 AAL68396 BC012789 BC016443 AAH16443 BC021272 BC050326 AAH50326 BE302040 BU632773 XM_006723042 XP_006723105 XM_006723043 XP_006723106 XM_011526515 XP_011524817 XM_011526516 XP_011524818 NM_134444 NP_604393
Function May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. {ECO:0000269|PubMed:12093792, ECO:0000269|PubMed:22388039}.

NALP4 (C-20) - sc-50620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NALP4 (P-20) - sc-50623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NALP4 antibody - ab198911 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling NALP4 with ab198911 at a 1/40 dilution.

Anti-NALP4 antibody - ab105414 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NALP4 antibody (ab105414) at 1 µg/ml + K562 cell lysate

Anti-NALP4 antibody - ab47241 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 antibody - N-terminal - ab138606 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NALP4 antibody - N-terminal (ab138606) at 1/100 dilution + Uterus cell line lysate at 35 µg

Anti-NALP4 / NLRP4 Antibody (aa139-157) - LS-C148285 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa606-624) - LS-C148988 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149, AP) - LS-C246619 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149, APC) - LS-C246621 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149, FITC) - LS-C246623 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149, PE) - LS-C246624 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149, Azide-free, HRP) - LS-C248928 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa120-149) - LS-C323372 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NALP4 / NLRP4 Antibody (aa121-149) - LS-C158401 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NLRP4 Antibody western blot of Uterus tissue lysates (35 ug/lane). The NLRP4 antibody detected the NLRP4 protein (arrow).

Anti-NALP4 / NLRP4 Antibody (Internal) - LS-C115896 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of NALP4 in K562 cell lysate with NALP4 antibody at 1 ug/ml.

Anti-NALP4 / NLRP4 Antibody (aa121-149, Biotin) - LS-C246622 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

NALP4 Antibody - NB100-56156 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal

NALP4 Antibody - NBP2-31375 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal

NALP4 Antibody - NBP1-85554 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NALP4 Antibody - NBP1-76288 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

NALP4 Polyclonal Antibody - bs-6855R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti NALP4 Polyclonal Antibody, Unconjugated (bs-6855R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-NLRP4 (91-105) antibody produced in rabbit - SAB1103889 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NLRP4 was separated on SDS-PAGE, blotted with Anti-NLRP4 (91-105) (<B>Cat. No. SAB1103889</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

Anti-NALP4 antibody produced in rabbit - SAB3500548 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NALP4: <B>Cat. No. SAB3500548</B>: NALP4 in K562 cell lysate with NALP4 antibody at 1 μg/mL.

Anti-NLRP4 antibody produced in rabbit - HPA042561 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NLRP4: <B>Cat. No. HPA042561</B>: Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cell.
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