| Gene Symbol |
NLRP4
|
| Entrez Gene |
147945
|
| Alt Symbol |
CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 4
|
| Other Description |
NACHT, LRR and PYD containing protein 4|NACHT, LRR and PYD domains-containing protein 4|NACHT, leucine rich repeat and PYD containing 4|PAAD and NACHT-containing protein 2|PYRIN and NACHT-containing protein 2|PYRIN-containing APAF1-like protein 4|cancer/testis antigen 58|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4|ribonuclease inhibitor 2
|
| Swissprots |
Q96AY6 Q86W87 Q96MN2
|
| Accessions |
EAW72417 EAW72418 Q96MN2 AF442488 AAL35293 AF479747 AAL87104 AF482706 AAL88672 AK056688 BAB71254 AK315003 BAG37498 AY072792 AAL68396 BC012789 BC016443 AAH16443 BC021272 BC050326 AAH50326 BE302040 BU632773 XM_006723042 XP_006723105 XM_006723043 XP_006723106 XM_011526515 XP_011524817 XM_011526516 XP_011524818 NM_134444 NP_604393
|
| Function |
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. {ECO:0000269|PubMed:12093792, ECO:0000269|PubMed:22388039}.
|