NLRP4

Gene Symbol NLRP4
Entrez Gene 147945
Alt Symbol CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
Species Human
Gene Type protein-coding
Description NLR family, pyrin domain containing 4
Other Description NACHT, LRR and PYD containing protein 4|NACHT, LRR and PYD domains-containing protein 4|NACHT, leucine rich repeat and PYD containing 4|PAAD and NACHT-containing protein 2|PYRIN and NACHT-containing protein 2|PYRIN-containing APAF1-like protein 4|cancer/testis antigen 58|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4|ribonuclease inhibitor 2
Swissprots Q96AY6 Q86W87 Q96MN2
Accessions EAW72417 EAW72418 Q96MN2 AF442488 AAL35293 AF479747 AAL87104 AF482706 AAL88672 AK056688 BAB71254 AK315003 BAG37498 AY072792 AAL68396 BC012789 BC016443 AAH16443 BC021272 BC050326 AAH50326 BE302040 BU632773 XM_006723042 XP_006723105 XM_006723043 XP_006723106 XM_011526515 XP_011524817 XM_011526516 XP_011524818 NM_134444 NP_604393
Function May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. {ECO:0000269|PubMed:12093792, ECO:0000269|PubMed:22388039}.

NALP4 CRISPR/Cas9 KO Plasmid (h) - sc-409047 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 HDR Plasmid (h) - sc-409047-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 Double Nickase Plasmid (h) - sc-409047-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 Double Nickase Plasmid (h2) - sc-409047-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 CRISPR Activation Plasmid (h) - sc-409047-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 CRISPR Activation Plasmid (h2) - sc-409047-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 Lentiviral Activation Particles (h) - sc-409047-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 Lentiviral Activation Particles (h2) - sc-409047-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP4 siRNA (h) - sc-61144 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NALP4 shRNA Plasmid (h) - sc-61144-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NALP4 shRNA (h) Lentiviral Particles - sc-61144-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

USP52 RNAi - H00009924-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU141341 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15356 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15356 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02411 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02411

NLRP4 siRNA (Human) - CRJ5553 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NLRP4 (NM_134444.4) - SHH352976 from Creative biogene

Category siRNA
Species Reactivities Human

NLRP4 shRNA Plasmid (Human) - CHJ5553 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NLRP4 miRNA 3'UTR clone - MiUTR4H-TG06036 from Creative biogene

Species Reactivities Human
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