BCL11A

Gene Symbol BCL11A
Entrez Gene 53335
Alt Symbol BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, EVI9, HBFQTL5, ZNF856
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 11A (zinc finger protein)
Other Description B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2|B-cell lymphoma/leukemia 11A|BCL-11A|BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1|C2H2-type zinc finger protein|COUP-TF-interacting protein 1|EVI-9|ecotropic viral integration site 9 homolog|ecotropic viral integration site 9 protein homolog|zinc finger protein 856
Swissprots Q9H163 Q8WU92 Q9NWA7 D6W5D7 Q9H164 Q9H165 Q86W14 Q96JL6 Q9H3G9
Accessions AAX93205 AAY14784 ADL14507 ADL14508 EAX00035 EAX00036 EAX00037 EAX00038 EAX00039 EAX00040 EAX00041 Q9H165 AB058712 BAB47438 AF080216 AAG49025 AJ404611 CAC17723 AJ404612 CAC17724 AJ404613 CAC17725 AK001035 AK055251 BAG51490 AK092316 BAG52530 AK297507 BAG59920 AK300012 BAG61828 AY228763 AAO88272 AY692278 AAU04557 BC021098 AAH21098 BG393787 EU446622 ABZ92151 EU446808 ABZ92337 JN852960 AEV45616 XM_011532909 XP_011531211 XM_011532910 XP_011531212 XM_011532911 XP_011531213 XM_011532912 XP_011531214 XM_011532913 XP_011531215 XM_011532914 XP_011531216 XM_011532915 XP_011531217 NM_018014 NP_060484 NM_022893 NP_075044 NM_138559 NP_612569 NM_138553
Function Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11161790}. Nucleus {ECO:0000269|PubMed:11161790}. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity). {ECO:0000250}.
Tissue Specificity Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. {ECO:0000269|PubMed:11161790, ECO:0000269|PubMed:11719382}.

Bcl-11a (C-12) - sc-33093 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Bcl-11a (H-116) - sc-366825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-11a (H-116): sc-366825. Western blot analysis of Bcl-11a expression in HEL 92.1.7 whole cell lysate.

Bcl-11a/b (Q-19) - sc-33095 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bcl-11b (Q-19): sc-33095. Western blot analysis of Bcl-11b expression in THP-1 (A), K-562 (B) and Jurkat (C) nuclear extracts.

Bcl-11a/b (S-16) - sc-33092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Ctip1 + Ctip2 antibody - ab82702 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Ctip1 [EPR14943-2] antibody - ab191402 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14943-2
All lanes : Anti-Ctip1 [EPR14943-2] antibody (ab191402) at 1/20000 dilutionLane 1 : Raji cell lysateLane 2 : Jurkat cell lysateLane 3 : 293 cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-Ctip1 [EPR14943-44] antibody - ab191401 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14943-44
All lanes : Anti-Ctip1 [EPR14943-44] antibody (ab191401) at 1/50000 dilutionLane 1 : Raji cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 20 µg per lane.Secondarygoat anti-rabbit IgG, (H+L), peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-Ctip1 antibody - ab154574 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ctip1 antibody (ab154574) at 1/2000 dilutionLane 1 : Jurkat whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Ctip1 antibody - ab86108 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Ctip1 antibody (ab86108) at 1 µg/ml + human fetal heart lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Ctip1 antibody - ab72247 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Ctip1 antibody (ab72247) at 1 µg/mlLane 2 : Anti-Ctip1 antibody (ab72247) at 0.1 µg/mlLane 1 : Nuclear extract from Raji cellsLane 2 : Nuclear extract from Raji cellsLysates/proteins at 50 µg per lane.

Anti-Ctip1 antibody - ab111168 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111168 at 1/50 dilution staining Ctip1 in paraffin-embedded Human lung carcinoma tissue by Immunohistochemistry. The image on the right is treated with synthesized peptide.

Anti-Ctip1 antibody - ab103247 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ctip1 antibody (ab103247) at 1/100 dilutionLane 1 : Jurkat cell lysateLane 2 : Ramos cell lysateLane 3 : 293 cell lysateLane 4 : NCI-H460 cell lysateLysates/proteins at 35 µg per lane.

Anti-Ctip1 antibody [14B5] - ab19487 from Abcam

Prices $392.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14B5
Overlay histogram showing Ramos cells stained with ab19487 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab19487, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in Ramos cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Ctip1 antibody [15E3AC11] - ab18688 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 15E3AC11
Overlay histogram showing RAMOS cells stained with ab18688(red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab18688, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG3 [MG3-35](ab18394, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-Ctip1 antibody [18B12DE6] - ChIP Grade - ab19489 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 18B12DE6
Human normal tonsil. Staining is localised to cytoplasm and nuclei. Left panel: with primary antibody at 4 ug/ml. Right panel: isotype control. Sections were stained using an automated system DAKO Autostainer Plus , at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers citrate EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for mouse for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-Ctip1 antibody [3D9] - ab124352 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D9
ab124352, at 5µg/ml, staining Ctip1 in formalin-fixed paraffin-embedded Human heart tissue by Immunohistochemistry.

Anti-BCL11A Antibody (aa1-50) - LS-C74735 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BCL11A Antibody (C-Terminus) - LS-C74737 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL11A Antibody (aa806-835, PE) - LS-C252455 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL11A Antibody (N-Terminus) - LS-C170186 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCL11A antibody Western Blot of Rat Spleen. Antibody dilution: 1 ug/ml.

Anti-BCL11A Antibody (aa806-835, AP) - LS-C252945 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL11A Antibody (aa806-835, APC) - LS-C252946 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL11A Antibody (C-Terminus) - LS-C135082 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BCL11A antibody LS-C135082 Western blot of PANC1 cell lysate.

Anti-BCL11A Antibody (aa806-835) - LS-C156769 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of BCL11A Antibody in Jurkat, Ramos, 293, NCI-H460 cell line lysates (35 ug/lane). BCL11A (arrow) was detected using the purified antibody.

Anti-BCL11A Antibody (C-Terminus) - LS-C186646 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Stomach Tumor. BCL11A antibody dilution 1.0 ug/ml.
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