PTGES3

Gene Symbol PTGES3
Entrez Gene 10728
Alt Symbol P23, TEBP, cPGES
Species Human
Gene Type protein-coding
Description prostaglandin E synthase 3 (cytosolic)
Other Description Hsp90 co-chaperone|cytosolic prostaglandin E synthase|cytosolic prostaglandin E2 synthase|progesterone receptor complex p23|prostaglandin E synthase 3|telomerase-binding protein p23|unactive progesterone receptor, 23 kD
Swissprots Q8WU70 B4DHP2 A8K7D0 B4DP21 Q15185 B4DP11
Accessions EAW96953 EAW96954 EAW96955 EAW96956 EAW96957 EAW96958 Q15185 AK098214 BAG53594 AK291945 BAF84634 AK293139 BAG56687 AK295208 BAG58204 AK298147 BAG60423 AK298160 BAG60433 AL603017 BC003005 AAH03005 BC021167 AAH21167 BG927063 BM541503 BP194632 BU167210 BU732883 CA773263 DA556848 DQ896710 ABM87709 EU176396 ABW03847 L24804 AAA18537 Z69891 XM_005268576 XP_005268633 XM_006719199 XP_006719262 XM_011537773 XP_011536075 XM_011537774 XP_011536076 NM_001282601 NP_001269530 NM_001282602 NP_001269531 NM_001282603 NP_001269532 NM_001282604 NP_001269533 NM_001282605 NP_001269534 NM_006601 NP_006592 NR_104219
Function Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
Subcellular Location Cytoplasm.
Top Pathways Arachidonic acid metabolism

P23 (G-7) - sc-376725 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P23 (G-7): sc-376725. Western blot analysis of P23 expression in A549 (A) and HeLa (B) whole cell lysates.

P23 (JJ6) - sc-101496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P23 (JJ6): sc-101496. Western blot analysis of P23 expression in non-transfected 293T: sc-117752 (A), mouse P23 transfected 293T: sc-122310 (B) and Jurkat (C) whole cell lysates.

P23 (B-5) - sc-377392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P23 (B-5): sc-377392. Western blot analysis of P23 expression in A549 (A) and HeLa (B) whole cell lysates.

P23 (H-60) - sc-68399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
P23 (H-60): sc-68399. Western blot analysis of P23 expression in 293T whole cell lysate.

P23 (JJ12) - sc-101497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

P23 (G-17) - sc-66256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P23 (G-17): sc-66256. Western blot analysis of P23 expression in heat shock-treated HeLa (A), A549 (B) and NIH/3T3 (C) whole cell lysates.

P23 (D-16) - sc-66254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P23 (D-16): sc-66254. Western blot analysis of P23 expression in heat shock-treated HeLa (A) and NIH/3T3 (B) whole cell lysates.

Anti-p23 (phospho S113) antibody - ab60968 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60968 at 1/50 - 1/100 dilution staining p23 in human colon carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-p23 antibody - ab74111 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-p23 antibody (ab74111) at 1/500 dilutionLane 1 : Extracts from NIH/3T3 cells treated with EGF (200ng/ml, 30mins)Lane 2 : Extracts from NIH/3T3 cells treated with EGF (200ng/ml, 30mins), plus peptide at 10 µgLysates/proteins at 5 µg per lane.

Anti-p23 antibody - ab123564 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-p23 antibody (ab123564) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-p23 antibody - ab95460 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : p23 antibody (ab95460) at 1/200 dilution on an SDS-PAGE gel Lane 1 : recombinant p23 protein (the immunogen) at 0.01 µg Lane 2 : recombinant p23 protein (the immunogen) at 0.02 µg Expected band size: 18.6 kDa Observed band size: 23 kDa

Anti-p23 antibody [EPR3846] - ab92503 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3846
All lanes : Anti-p23 antibody [EPR3846] (ab92503) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : Human spleen lysateLane 3 : Jurkat cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP-labeled goat anti-rabbit at 1/2000 dilution

Anti-PTGES3 Antibody (C-Terminus) - LS-C112176 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTGES3 antibody LS-C112176 Western blot of PANC1 cell lysate.

Anti-PTGES3 Antibody (aa35-84) - LS-C116787 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTGES3 antibody LS-C116787 Western blot of COLO205 cell lysate.

Anti-PTGES3 Antibody - LS-C137394 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PTGES3 Antibody (clone JJ6, Atto 390) - LS-C230539 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody (aa79-128) - LS-C117718 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human breast carcinoma tissue, using TEBP (Ab-113) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-PTGES3 Antibody IHC-plus™ - LS-B6976 from LifeSpan Bioscience

Prices $395.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Anti-PTGES3 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6976 concentration 5 ug/ml.

Anti-PTGES3 Antibody (clone JJ6, Atto 488) - LS-C230540 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody - LS-C146646 from LifeSpan Bioscience

Prices $305.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Western blot of PTGES3 antibody LS-C146646.

Anti-PTGES3 Antibody (clone JJ6, Atto 565) - LS-C230541 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody (clone JJ6, Atto 633) - LS-C230543 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody (clone JJ6, Atto 594) - LS-C230542 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody (clone JJ6, Atto 655) - LS-C230544 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JJ6

Anti-PTGES3 Antibody (Internal, clone EPR3846) - LS-C105668 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3846
Immunofluorescent staining of HeLa cells using anti-Prostaglandin E Synthase 3 antibody (LS-C105668).
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