| Gene Symbol | PTGES3 |
|---|---|
| Entrez Gene | 10728 |
| Alt Symbol | P23, TEBP, cPGES |
| Species | Human |
| Gene Type | protein-coding |
| Description | prostaglandin E synthase 3 (cytosolic) |
| Other Description | Hsp90 co-chaperone|cytosolic prostaglandin E synthase|cytosolic prostaglandin E2 synthase|progesterone receptor complex p23|prostaglandin E synthase 3|telomerase-binding protein p23|unactive progesterone receptor, 23 kD |
| Swissprots | Q8WU70 B4DHP2 A8K7D0 B4DP21 Q15185 B4DP11 |
| Accessions | EAW96953 EAW96954 EAW96955 EAW96956 EAW96957 EAW96958 Q15185 AK098214 BAG53594 AK291945 BAF84634 AK293139 BAG56687 AK295208 BAG58204 AK298147 BAG60423 AK298160 BAG60433 AL603017 BC003005 AAH03005 BC021167 AAH21167 BG927063 BM541503 BP194632 BU167210 BU732883 CA773263 DA556848 DQ896710 ABM87709 EU176396 ABW03847 L24804 AAA18537 Z69891 XM_005268576 XP_005268633 XM_006719199 XP_006719262 XM_011537773 XP_011536075 XM_011537774 XP_011536076 NM_001282601 NP_001269530 NM_001282602 NP_001269531 NM_001282603 NP_001269532 NM_001282604 NP_001269533 NM_001282605 NP_001269534 NM_006601 NP_006592 NR_104219 |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Arachidonic acid metabolism |