PTGES3

Gene Symbol	PTGES3
Entrez Gene	10728
Alt Symbol	P23, TEBP, cPGES
Species	Human
Gene Type	protein-coding
Description	prostaglandin E synthase 3 (cytosolic)
Other Description	Hsp90 co-chaperone|cytosolic prostaglandin E synthase|cytosolic prostaglandin E2 synthase|progesterone receptor complex p23|prostaglandin E synthase 3|telomerase-binding protein p23|unactive progesterone receptor, 23 kD
Swissprots	Q8WU70 B4DHP2 A8K7D0 B4DP21 Q15185 B4DP11
Accessions	EAW96953 EAW96954 EAW96955 EAW96956 EAW96957 EAW96958 Q15185 AK098214 BAG53594 AK291945 BAF84634 AK293139 BAG56687 AK295208 BAG58204 AK298147 BAG60423 AK298160 BAG60433 AL603017 BC003005 AAH03005 BC021167 AAH21167 BG927063 BM541503 BP194632 BU167210 BU732883 CA773263 DA556848 DQ896710 ABM87709 EU176396 ABW03847 L24804 AAA18537 Z69891 XM_005268576 XP_005268633 XM_006719199 XP_006719262 XM_011537773 XP_011536075 XM_011537774 XP_011536076 NM_001282601 NP_001269530 NM_001282602 NP_001269531 NM_001282603 NP_001269532 NM_001282604 NP_001269533 NM_001282605 NP_001269534 NM_006601 NP_006592 NR_104219
Function	Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
Subcellular Location	Cytoplasm.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p23 full length protein - ab113183 from Abcam Category Protein Source E. coli Species Human

Human p23 full length protein - ab75542 from Abcam Category Protein Source E. coli Species Human

Human p23 full length protein - ab89361 from Abcam Category Protein Source E. coli Species Human

PTGES3 Antibody Blocking Peptide - LS-E3554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTGES3 Antibody Blocking Peptide - LS-E21331 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTGES3 Antibody Blocking Peptide - LS-E21332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

p23/PTGES3 Recombinant Protein - H00010728-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human p23/PTGES3 Protein - NBP1-30281 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

PTGES3-Antibody-Center-Blocking-Peptide - BP14751c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human p23/PTGES3, CF - AP-170-050 from R&D Systems Category Protein

PTGES3 Protein (OPPA02187) - OPPA02187 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human PTGES3 protein - orb90255 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Prostagladin E synthase 3 protein - 30R-1418 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

PTGES3 Blocking Peptide - 33R-4309 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTGES3 / TEBP (1-160) - AR09301PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

PTGES3 / TEBP (1-160) - AR09301PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

PTGES3 / TEBP - H00010728-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PTGES3 / TEBP - H00010728-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Prostaglandin E Synthase 3, Human Recombinant - 228-12478-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Prostaglandin E Synthase 3 - 228-12478-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Prostaglandin E Synthase 3 - 228-12478-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

Prostagladin E synthase 3, 1-160 aa, Human, E.coli - 01-2188 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

PTGES3 fusion protein - Ag7870 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PTGES3 fusion protein - Ag7384 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PTGES3 Human - ENPS-465 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

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