Gene Symbol | TRAF7 |
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Entrez Gene | 84231 |
Alt Symbol | RFWD1, RNF119 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase TRAF7|RING finger and WD repeat-containing protein 1|RING finger protein 119|ring finger and WD repeat domain 1 |
Swissprots | Q9H073 Q6Q0C0 |
Accessions | EAW85546 EAW85547 EAW85548 EAW85549 Q6Q0C0 AK090624 BAG52199 AL136921 CAB66855 AW245178 AY569455 AAS68363 BC024267 XM_005255627 XP_005255684 XM_011522700 XP_011521002 NM_206835 NM_032271 NP_115647 |
Function | E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576}. |
Subcellular Location | Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. |
Tissue Specificity | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. {ECO:0000269|PubMed:15001576}. |
TRAF7 (D-19) - sc-49545 from Santa Cruz Biotechnology
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TRAF7 (H-300) - sc-98963 from Santa Cruz Biotechnology
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TRAF7 (W-18) - sc-49547 from Santa Cruz Biotechnology
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Anti-TRAF7 antibody - ab192382 from Abcam
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Anti-TRAF7 antibody - N-terminal - ab200451 from Abcam
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Anti-TRAF7 Antibody - LS-C332355 from LifeSpan Bioscience
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Anti-TRAF7 Antibody - LS-C90673 from LifeSpan Bioscience
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Anti-TRAF7 Antibody (aa334-356) - LS-C148051 from LifeSpan Bioscience
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Anti-TRAF7 Antibody - LS-C341537 from LifeSpan Bioscience
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Anti-TRAF7 Antibody (aa35-84) - LS-C107678 from LifeSpan Bioscience
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TRAF7 Antibody - NB600-1399 from Novus Biologicals
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TRAF7 Antibody - NBP1-58999 from Novus Biologicals
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TRAF7 Antibody - NBP1-85068 from Novus Biologicals
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TRAF7 Polyclonal Antibody - bs-7676R from Bioss
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Anti-TRAF7 antibody produced in rabbit - HPA041229 from Sigma-Aldrich
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Anti-TRAF7, (N-terminal) antibody produced in rabbit - SAB2104869 from Sigma-Aldrich
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TRAF7 antibody - N-terminal region (ARP43355_P050) - ARP43355_P050 from Aviva Systems Biology
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TRAF7 antibody - 70R-5931 from Fitzgerald
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TRAF7 antibody - 70R-20959 from Fitzgerald
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TRAF7 Polyclonal Antibody - A3095 from ABclonal
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TRAF7 antibody - orb101190 from Biorbyt
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Tnf Receptor-Associated Factor 7 Antibody - abx116117 from Abbexa
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TRAF7 Antibody - abx002225 from Abbexa
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TRAF7 / RNF119 antibody - 11780-1-AP from Acris Antibodies
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TRAF7 / RNF119 antibody - PAB0781 from Acris Antibodies
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