Gene Symbol | TRAF7 |
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Entrez Gene | 84231 |
Alt Symbol | RFWD1, RNF119 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase TRAF7|RING finger and WD repeat-containing protein 1|RING finger protein 119|ring finger and WD repeat domain 1 |
Swissprots | Q9H073 Q6Q0C0 |
Accessions | EAW85546 EAW85547 EAW85548 EAW85549 Q6Q0C0 AK090624 BAG52199 AL136921 CAB66855 AW245178 AY569455 AAS68363 BC024267 XM_005255627 XP_005255684 XM_011522700 XP_011521002 NM_206835 NM_032271 NP_115647 |
Function | E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576}. |
Subcellular Location | Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. |
Tissue Specificity | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. {ECO:0000269|PubMed:15001576}. |
Human TRAF7 full length protein - ab164530 from Abcam
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Human TRAF7 protein fragment - ab164531 from Abcam
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TRAF7 Antibody Blocking Peptide - LS-E15949 from LifeSpan Bioscience
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TRAF7 Partial Recombinant Protein - H00084231-Q01 from Novus Biologicals
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Recombinant Human TRAF7 Protein - H00084231-P01 from Novus Biologicals
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TRAF7 Blocking Peptide - 33R-3462 from Fitzgerald
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TRAF7 / RNF119 - H00084231-P01-10 from Acris Antibodies
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TRAF7 / RNF119 - H00084231-P01-25 from Acris Antibodies
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TRAF7 / RNF119 - H00084231-Q01-10 from Acris Antibodies
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TRAF7 / RNF119 - H00084231-Q01-25 from Acris Antibodies
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TRAF7 fusion protein - ag15273 from Proteintech Group
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TRAF7 fusion protein - ag2414 from Proteintech Group
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Recombinant Human E3 ubiquitin-protein ligase TRAF7(TRAF7) - CSB-YP757671HU CSB-EP757671HU CSB-BP757671HU CSB-MP757671HU from Cusabio
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TRAF7 Recombinant Protein Antigen - NBP1-85068PEP from Novus Biologicals
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TRAF7 Peptide, Human - M34GP16521H from Creative Peptides
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E3 ubiquitin-protein ligase TRAF7 (TRAF7), Recombinant Protein - MBS1401838 from MyBioSource
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