| Gene Symbol |
TRAF7
|
| Entrez Gene |
84231
|
| Alt Symbol |
RFWD1, RNF119
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TNF receptor-associated factor 7, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase TRAF7|RING finger and WD repeat-containing protein 1|RING finger protein 119|ring finger and WD repeat domain 1
|
| Swissprots |
Q9H073 Q6Q0C0
|
| Accessions |
EAW85546 EAW85547 EAW85548 EAW85549 Q6Q0C0 AK090624 BAG52199 AL136921 CAB66855 AW245178 AY569455 AAS68363 BC024267 XM_005255627 XP_005255684 XM_011522700 XP_011521002 NM_206835 NM_032271 NP_115647
|
| Function |
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576}.
|
| Subcellular Location |
Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
|
| Tissue Specificity |
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. {ECO:0000269|PubMed:15001576}.
|