Gene Symbol | TRAF7 |
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Entrez Gene | 84231 |
Alt Symbol | RFWD1, RNF119 |
Species | Human |
Gene Type | protein-coding |
Description | TNF receptor-associated factor 7, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase TRAF7|RING finger and WD repeat-containing protein 1|RING finger protein 119|ring finger and WD repeat domain 1 |
Swissprots | Q9H073 Q6Q0C0 |
Accessions | EAW85546 EAW85547 EAW85548 EAW85549 Q6Q0C0 AK090624 BAG52199 AL136921 CAB66855 AW245178 AY569455 AAS68363 BC024267 XM_005255627 XP_005255684 XM_011522700 XP_011521002 NM_206835 NM_032271 NP_115647 |
Function | E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576}. |
Subcellular Location | Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. |
Tissue Specificity | Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. {ECO:0000269|PubMed:15001576}. |
TRAF7 CRISPR/Cas9 KO Plasmid (h) - sc-404992 from Santa Cruz Biotechnology
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TRAF7 HDR Plasmid (h) - sc-404992-HDR from Santa Cruz Biotechnology
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TRAF7 Double Nickase Plasmid (h) - sc-404992-NIC from Santa Cruz Biotechnology
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TRAF7 Double Nickase Plasmid (h2) - sc-404992-NIC-2 from Santa Cruz Biotechnology
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TRAF7 CRISPR Activation Plasmid (h) - sc-404992-ACT from Santa Cruz Biotechnology
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TRAF7 CRISPR Activation Plasmid (h2) - sc-404992-ACT-2 from Santa Cruz Biotechnology
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TRAF7 Lentiviral Activation Particles (h) - sc-404992-LAC from Santa Cruz Biotechnology
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TRAF7 Lentiviral Activation Particles (h2) - sc-404992-LAC-2 from Santa Cruz Biotechnology
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TRAF7 siRNA (h) - sc-61704 from Santa Cruz Biotechnology
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TRAF7 shRNA Plasmid (h) - sc-61704-SH from Santa Cruz Biotechnology
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TRAF7 shRNA (h) Lentiviral Particles - sc-61704-V from Santa Cruz Biotechnology
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TRAF7 RNAi - H00084231-R01 from Novus Biologicals
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MISSION® esiRNA - EHU071571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21911 from Sigma-Aldrich
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TRAF7 siRNA (Human) - CRJ3366 from Cohesion Biosciences
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TRAF7 RNAi - H00084231-R02 from Novus Biologicals
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TRAF7 - MBS8237713 from MyBioSource
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shRNA set against Human TRAF7 (NM_032271.2) - SHH433784 from Creative biogene
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shRNA set against Human TRAF7(NM_032271.2) - SHL091264 from Creative biogene
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Human TRAF7 siRNA - orb273867 from Biorbyt
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TRAF7 shRNA Plasmid (Human) - CHJ3366 from Cohesion Biosciences
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TRAF7 miRNA 3'UTR clone - MiUTR3H-08662 from Creative biogene
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