| Gene Symbol |
MGEA5
|
| Entrez Gene |
10724
|
| Alt Symbol |
MEA5, NCOAT, OGA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
meningioma expressed antigen 5 (hyaluronidase)
|
| Other Description |
N-acetyl-beta-D-glucosaminidase|N-acetyl-beta-glucosaminidase|O-GlcNAcase|beta-N-acetylglucosaminidase|beta-N-acetylhexosaminidase|beta-hexosaminidase|bifunctional protein NCOAT|hyaluronidase in meningioma|meningioma-expressed antigen 5|nuclear cytoplasmic O-GlcNAcase and acetyltransferase|protein O-GlcNAcase
|
| Swissprots |
Q9HAR0 O60502 Q86WV0 Q9BVA5 E9PGF9 O75166 B7WPB9 D3DR79 Q8IV98
|
| Accessions |
EAW49741 EAW49742 EAW49743 EAW49744 O60502 AB014579 BAA31654 AF036144 AAD05385 AF307332 AAG21428 AK000988 AK002091 BAG51014 AK027008 AK302626 BAG63869 BC001343 AAH01343 BC014201 BC032591 BC039583 AAH39583 BC047877 AAH47877 BQ016159 DC353958 XM_011539180 XP_011537482 XM_011539181 XP_011537483 XM_011539182 XP_011537484 XR_246060 XR_945587 XR_945588 NM_001142434 NP_001135906 NM_012215 NP_036347
|
| Function |
Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714}.
|
| Subcellular Location |
Isoform 3: Nucleus {ECO:0000269|PubMed:11341771}.
|
| Tissue Specificity |
Ubiquitous. Shows highest expression in the brain, placenta and pancreas. {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11341771}.
|