MGEA5
| Gene Symbol | MGEA5 |
|---|---|
| Entrez Gene | 10724 |
| Alt Symbol | MEA5, NCOAT, OGA |
| Species | Human |
| Gene Type | protein-coding |
| Description | meningioma expressed antigen 5 (hyaluronidase) |
| Other Description | N-acetyl-beta-D-glucosaminidase|N-acetyl-beta-glucosaminidase|O-GlcNAcase|beta-N-acetylglucosaminidase|beta-N-acetylhexosaminidase|beta-hexosaminidase|bifunctional protein NCOAT|hyaluronidase in meningioma|meningioma-expressed antigen 5|nuclear cytoplasmic O-GlcNAcase and acetyltransferase|protein O-GlcNAcase |
| Swissprots | Q9HAR0 O60502 Q86WV0 Q9BVA5 E9PGF9 O75166 B7WPB9 D3DR79 Q8IV98 |
| Accessions | EAW49741 EAW49742 EAW49743 EAW49744 O60502 AB014579 BAA31654 AF036144 AAD05385 AF307332 AAG21428 AK000988 AK002091 BAG51014 AK027008 AK302626 BAG63869 BC001343 AAH01343 BC014201 BC032591 BC039583 AAH39583 BC047877 AAH47877 BQ016159 DC353958 XM_011539180 XP_011537482 XM_011539181 XP_011537483 XM_011539182 XP_011537484 XR_246060 XR_945587 XR_945588 NM_001142434 NP_001135906 NM_012215 NP_036347 |
| Function | Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11788610, ECO:0000269|PubMed:20673219, ECO:0000269|PubMed:22365600, ECO:0000269|PubMed:24088714}. |
| Subcellular Location | Isoform 3: Nucleus {ECO:0000269|PubMed:11341771}. |
| Tissue Specificity | Ubiquitous. Shows highest expression in the brain, placenta and pancreas. {ECO:0000269|PubMed:11148210, ECO:0000269|PubMed:11341771}. |
Human MGEA5 full length protein - ab153117 from Abcam
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Human MGEA5 protein fragment - ab153118 from Abcam
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MGEA5 peptide - ab155521 from Abcam
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O-GlcNAcase/OGA/MGEA5 Recombinant Protein - H00010724-P01 from Novus Biologicals
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O-GlcNAcase/OGA/MGEA5 Partial Recombinant Protein - H00010724-Q01 from Novus Biologicals
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Recombinant Human O-GlcNAcase/OGA/MGEA5 Protein - NBP1-98959 from Novus Biologicals
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Recombinant B. thetaiotaomicron O-GlcNAcase/OGA, CF - 6779-GH-020 from R&D Systems
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Human NAGase Protein - abx068194 from Abbexa
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Human NAGase Protein - abx068189 from Abbexa
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MGEA5 - H00010724-P01-10 from Acris Antibodies
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MGEA5 - H00010724-P01-25 from Acris Antibodies
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MGEA5 - H00010724-Q01-10 from Acris Antibodies
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MGEA5 - H00010724-Q01-25 from Acris Antibodies
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N-Acetyl Beta-D-Glucosaminidase (NAGase), Human - 20-6184 from ARP American Research Products
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N-Acetyl Beta-D-Glucosaminidase (NAGase), Human - 20-6185 from ARP American Research Products
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MGEA5 fusion protein - Ag6905 from Proteintech Group
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MGEA5 fusion protein - Ag6405 from Proteintech Group
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Recombinant Human MGEA5, His-tagged - MGEA5-864H from Creative Biomart
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Recombinant Human MGEA5, MYC/DDK-tagged - MGEA5-86H from Creative Biomart
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Hu01 from Uscn Life Science Inc.
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Hu02 from Uscn Life Science Inc.
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Hu03 from Uscn Life Science Inc.
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Mu01 from Uscn Life Science Inc.
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Mu02 from Uscn Life Science Inc.
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Recombinant N-Acetyl Beta-D-Glucosaminidase (NAGase) - RPA069Mu03 from Uscn Life Science Inc.
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