| Gene Symbol |
ZMPSTE24
|
| Entrez Gene |
10269
|
| Alt Symbol |
FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc metallopeptidase STE24
|
| Other Description |
CAAX prenyl protease 1 homolog|farnesylated proteins-converting enzyme 1|prenyl protein-specific endoprotease 1|zinc metallopeptidase STE24 homolog|zinc metalloproteinase Ste24 homolog
|
| Swissprots |
Q9UBQ2 D3DPU7 O75844 B3KQI7 Q8NDZ8
|
| Accessions |
CAF85955 CAF86212 EAX07233 EAX07234 O75844 AA436253 AB016068 BAA33727 AF064867 AAC68866 AI003768 AK027874 BAG51388 AK074784 AK075007 BAG52049 BC037283 AAH37283 DA398037 DB096663 DB285015 EU176257 ABW03708 EU176564 ABW03365 Y13834 CAB46277 XM_011540486 XP_011538788 XM_011540487 XP_011538789 NM_005857 NP_005848
|
| Function |
Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}. Nucleus inner membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}.
|
| Tissue Specificity |
Widely expressed. High levels in kidney, prostate, testis and ovary.
|
| Top Pathways |
Terpenoid backbone biosynthesis
|