Gene Symbol | ZMPSTE24 |
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Entrez Gene | 10269 |
Alt Symbol | FACE-1, FACE1, HGPS, PRO1, STE24, Ste24p |
Species | Human |
Gene Type | protein-coding |
Description | zinc metallopeptidase STE24 |
Other Description | CAAX prenyl protease 1 homolog|farnesylated proteins-converting enzyme 1|prenyl protein-specific endoprotease 1|zinc metallopeptidase STE24 homolog|zinc metalloproteinase Ste24 homolog |
Swissprots | Q9UBQ2 D3DPU7 O75844 B3KQI7 Q8NDZ8 |
Accessions | CAF85955 CAF86212 EAX07233 EAX07234 O75844 AA436253 AB016068 BAA33727 AF064867 AAC68866 AI003768 AK027874 BAG51388 AK074784 AK075007 BAG52049 BC037283 AAH37283 DA398037 DB096663 DB285015 EU176257 ABW03708 EU176564 ABW03365 Y13834 CAB46277 XM_011540486 XP_011538788 XM_011540487 XP_011538789 NM_005857 NP_005848 |
Function | Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}. Nucleus inner membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}. |
Tissue Specificity | Widely expressed. High levels in kidney, prostate, testis and ovary. |
Top Pathways | Terpenoid backbone biosynthesis |
FACE-1 CRISPR/Cas9 KO Plasmid (h) - sc-403350 from Santa Cruz Biotechnology
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FACE-1 HDR Plasmid (h) - sc-403350-HDR from Santa Cruz Biotechnology
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FACE-1 Double Nickase Plasmid (h) - sc-403350-NIC from Santa Cruz Biotechnology
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FACE-1 Double Nickase Plasmid (h2) - sc-403350-NIC-2 from Santa Cruz Biotechnology
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FACE-1 CRISPR Activation Plasmid (h) - sc-403350-ACT from Santa Cruz Biotechnology
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FACE-1 CRISPR Activation Plasmid (h2) - sc-403350-ACT-2 from Santa Cruz Biotechnology
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FACE-1 Lentiviral Activation Particles (h) - sc-403350-LAC from Santa Cruz Biotechnology
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FACE-1 Lentiviral Activation Particles (h2) - sc-403350-LAC-2 from Santa Cruz Biotechnology
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FACE-1 siRNA (h) - sc-45524 from Santa Cruz Biotechnology
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FACE-1 shRNA Plasmid (h) - sc-45524-SH from Santa Cruz Biotechnology
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FACE-1 shRNA (h) Lentiviral Particles - sc-45524-V from Santa Cruz Biotechnology
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ZMPSTE24 RNAi - H00010269-R01 from Novus Biologicals
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MISSION® esiRNA - EHU035891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23238 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23238 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12695 from Sigma-Aldrich
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ZMPSTE24 siRNA (Human) - CRH6952 from Cohesion Biosciences
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ZMPSTE24 - MBS8212866 from MyBioSource
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shRNA set against Human ste2 (NM_005857.4) - SHH419532 from Creative biogene
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Human ZMPSTE24 siRNA - orb267454 from Biorbyt
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ZMPSTE24 shRNA Plasmid (Human) - CHH6952 from Cohesion Biosciences
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ZMPSTE24 miRNA 3'UTR clone - MiUTR3H-08496 from Creative biogene
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