| Gene Symbol |
WDR82
|
| Entrez Gene |
80335
|
| Alt Symbol |
MST107, MSTP107, PRO2730, PRO34047, SWD2, TMEM113, WDR82A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain 82
|
| Other Description |
WD repeat-containing protein 82|transmembrane protein 113
|
| Swissprots |
Q8TEB2 A8K5R5 Q6UXN9
|
| Accessions |
EAW65202 EAW65203 Q6UXN9 AF132207 AAG35553 AF173977 AAQ13620 AI478905 AK074290 BAB85039 AK098435 AK123860 AK130177 AK291380 BAF84069 AY358264 AAQ88631 BC011760 AAH11760 BC018941 AAH18941 BX648628 DB500464 XM_011534136 XP_011532438 XM_011534137 XP_011532439 NM_025222 NP_079498
|
| Function |
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:17998332, ECO:0000269|PubMed:18838538, ECO:0000269|PubMed:20516061}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16253997, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20516061}. Note=Associates with chromatin.
|
| Top Pathways |
mRNA surveillance pathway
|