Gene Symbol | WDR82 |
---|---|
Entrez Gene | 80335 |
Alt Symbol | MST107, MSTP107, PRO2730, PRO34047, SWD2, TMEM113, WDR82A |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 82 |
Other Description | WD repeat-containing protein 82|transmembrane protein 113 |
Swissprots | Q8TEB2 A8K5R5 Q6UXN9 |
Accessions | EAW65202 EAW65203 Q6UXN9 AF132207 AAG35553 AF173977 AAQ13620 AI478905 AK074290 BAB85039 AK098435 AK123860 AK130177 AK291380 BAF84069 AY358264 AAQ88631 BC011760 AAH11760 BC018941 AAH18941 BX648628 DB500464 XM_011534136 XP_011532438 XM_011534137 XP_011532439 NM_025222 NP_079498 |
Function | Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:17998332, ECO:0000269|PubMed:18838538, ECO:0000269|PubMed:20516061}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16253997, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20516061}. Note=Associates with chromatin. |
Top Pathways | mRNA surveillance pathway |
WDR82 CRISPR/Cas9 KO Plasmid (h) - sc-406963 from Santa Cruz Biotechnology
|
||||||||
WDR82 HDR Plasmid (h) - sc-406963-HDR from Santa Cruz Biotechnology
|
||||||||
WDR82 Double Nickase Plasmid (h) - sc-406963-NIC from Santa Cruz Biotechnology
|
||||||||
WDR82 Double Nickase Plasmid (h2) - sc-406963-NIC-2 from Santa Cruz Biotechnology
|
||||||||
WDR82 CRISPR Activation Plasmid (h) - sc-406963-ACT from Santa Cruz Biotechnology
|
||||||||
WDR82 CRISPR Activation Plasmid (h2) - sc-406963-ACT-2 from Santa Cruz Biotechnology
|
||||||||
WDR82 Lentiviral Activation Particles (h) - sc-406963-LAC from Santa Cruz Biotechnology
|
||||||||
WDR82 Lentiviral Activation Particles (h2) - sc-406963-LAC-2 from Santa Cruz Biotechnology
|
||||||||
WDR82 siRNA (h) - sc-78161 from Santa Cruz Biotechnology
|
||||||||
WDR82 shRNA Plasmid (h) - sc-78161-SH from Santa Cruz Biotechnology
|
||||||||
WDR82 shRNA (h) Lentiviral Particles - sc-78161-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU115091 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN22861 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22861 from Sigma-Aldrich
|
||||||||
WDR82 siRNA (Human) - CRJ2864 from Cohesion Biosciences
|
||||||||
WDR82 - MBS8211473 from MyBioSource
|
||||||||
shRNA set against Human WDR82 (NM_025222.3) - SHH446572 from Creative biogene
|
||||||||
WDR82 shRNA Plasmid (Human) - CHJ2864 from Cohesion Biosciences
|
||||||||
WDR82 miRNA 3'UTR clone - MiUTR1H-10481 from Creative biogene
|