| Gene Symbol |
MSRB1
|
| Entrez Gene |
51734
|
| Alt Symbol |
HSPC270, SELR, SELX, SEPX1, SepR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methionine sulfoxide reductase B1
|
| Other Description |
methionine-R-sulfoxide reductase B1|selenoprotein R|selenoprotein X, 1
|
| Swissprots |
Q9NZV6 Q9BTV2 Q9P0B1 Q96RX6
|
| Accessions |
AAK61300 EAW85600 EAW85601 Q9NZV6 AF161388 AAF28948 AF166124 AAF21429 AF187272 AAG17033 AK026128 BC003127 AAH03127 CF134919 NM_016332 NP_057416
|
| Function |
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)- sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
|