Gene Symbol | MSRB1 |
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Entrez Gene | 51734 |
Alt Symbol | HSPC270, SELR, SELX, SEPX1, SepR |
Species | Human |
Gene Type | protein-coding |
Description | methionine sulfoxide reductase B1 |
Other Description | methionine-R-sulfoxide reductase B1|selenoprotein R|selenoprotein X, 1 |
Swissprots | Q9NZV6 Q9BTV2 Q9P0B1 Q96RX6 |
Accessions | AAK61300 EAW85600 EAW85601 Q9NZV6 AF161388 AAF28948 AF166124 AAF21429 AF187272 AAG17033 AK026128 BC003127 AAH03127 CF134919 NM_016332 NP_057416 |
Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)- sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
Selenoprotein R CRISPR/Cas9 KO Plasmid (h) - sc-406983 from Santa Cruz Biotechnology
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Selenoprotein R HDR Plasmid (h) - sc-406983-HDR from Santa Cruz Biotechnology
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Selenoprotein R Double Nickase Plasmid (h) - sc-406983-NIC from Santa Cruz Biotechnology
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Selenoprotein R Double Nickase Plasmid (h2) - sc-406983-NIC-2 from Santa Cruz Biotechnology
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Selenoprotein R CRISPR Activation Plasmid (h) - sc-406983-ACT from Santa Cruz Biotechnology
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Selenoprotein R CRISPR Activation Plasmid (h2) - sc-406983-ACT-2 from Santa Cruz Biotechnology
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Selenoprotein R Lentiviral Activation Particles (h) - sc-406983-LAC from Santa Cruz Biotechnology
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Selenoprotein R Lentiviral Activation Particles (h2) - sc-406983-LAC-2 from Santa Cruz Biotechnology
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Selenoprotein R siRNA (h) - sc-45574 from Santa Cruz Biotechnology
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Selenoprotein R shRNA Plasmid (h) - sc-45574-SH from Santa Cruz Biotechnology
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Selenoprotein R shRNA (h) Lentiviral Particles - sc-45574-V from Santa Cruz Biotechnology
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Methionine Sulfoxide Reductase B RNAi - H00051734-R01 from Novus Biologicals
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MISSION® esiRNA - EHU101381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19114 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19114 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06638 from Sigma-Aldrich
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MSRB1 siRNA (Human) - CRH9924 from Cohesion Biosciences
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shRNA set against Human SEPX1 (NM_016332.2) - SHH404700 from Creative biogene
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shRNA set against Human SEPX1(NM_016332.2) - SHH221352 from Creative biogene
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Human MSRB1 siRNA - orb270426 from Biorbyt
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MSRB1 shRNA Plasmid (Human) - CHH9924 from Cohesion Biosciences
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MSRB1 miRNA 3'UTR clone - MiUTR1H-09282 from Creative biogene
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