| Gene Symbol |
PPP1R16B
|
| Entrez Gene |
26051
|
| Alt Symbol |
ANKRD4, TIMAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 16B
|
| Other Description |
CAAX box protein TIMAP|TGF-beta-inhibited membrane-associated protein|ankyrin repeat domain protein 4|ankyrin repeat domain-containing protein 4|hTIMAP|protein phosphatase 1 regulatory inhibitor subunit 16B|protein phosphatase 1, regulatory (inhibitor) subunit 16B
|
| Swissprots |
Q9NQG4 Q96T49 Q5W9G4 O94912 E9PFS8 A2RRR6
|
| Accessions |
EAW76009 Q96T49 AB020630 BAA74846 AB177855 BAD66833 AF362910 AAK52796 AK026900 AK311244 BC026224 BC131801 AAI31802 BC152467 AAI52468 XM_011528768 XP_011527070 XM_011528769 XP_011527071 NM_001172735 NP_001166206 NM_015568 NP_056383
|
| Function |
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. {ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956}.
|
| Subcellular Location |
Cell membrane. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus. Note=Colocalizes with RPSA/LAMR1 in the cell membrane.
|
| Tissue Specificity |
Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis.
|