| Gene Symbol |
GPN1
|
| Entrez Gene |
11321
|
| Alt Symbol |
ATPBD1A, MBDIN, NTPBP, RPAP4, XAB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GPN-loop GTPase 1
|
| Other Description |
ATP(GTP)-binding protein|MBD2-interacting protein|RNA polymerase II associated protein 4|RNAPII-associated protein 4|XPA binding protein 1, GTPase
|
| Swissprots |
B4DXU4 B4DQJ5 O76004 B4DQM4 B5MBZ5 Q9HCN4
|
| Accessions |
AAX93201 EAX00557 EAX00558 Q9HCN4 AB044661 BAB17612 AJ010842 CAA09376 AK298827 BAG60957 AK298866 BAG60986 AK302131 BAG63506 AK310340 AK311423 AK312992 BAG35829 AK316404 BAH14775 BC007451 AAH07451 DQ893280 ABM84206 DQ896611 ABM87610 NM_001145047 NP_001138519 NM_001145048 NP_001138520 NM_001145049 NP_001138521 NM_007266 NP_009197 NR_026735
|
| Function |
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11058119, ECO:0000269|PubMed:20855544}. Nucleus {ECO:0000269|PubMed:20855544}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:20855544}.
|
| Tissue Specificity |
Expressed ubiquitously.
|