MAGEA2

Gene Symbol MAGEA2
Entrez Gene 4101
Alt Symbol CT1.2, MAGE2, MAGEA2A
Species Human
Gene Type protein-coding
Description melanoma antigen family A2
Other Description MAGE-2 antigen|cancer/testis antigen 1.2|cancer/testis antigen family 1, member 2|melanoma antigen 2|melanoma antigen family A, 2|melanoma-associated antigen 2
Swissprots Q32NC6 A8K328 P43356
Accessions AAA17729 EAW99429 EAW99430 EAW99431 P43356 AK290443 BAF83132 AU100045 BC013098 AAH13098 BC063681 AAH63681 BC108720 AAI08721 BC109188 AAI09189 BC112158 AAI12159 BC112160 AAI12161 BC146449 AAI46450 BG575302 BM781931 BX282627 CA429655 DR158683 XM_011531159 XP_011529461 NM_001282501 NP_001269430 NM_001282502 NP_001269431 NM_001282504 NP_001269433 NM_001282505 NP_001269434 NM_005361 NP_005352 NM_175742 NP_786884 NM_175743 NP_786885
Function Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T- lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation. {ECO:0000269|PubMed:16847267, ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:22117195}.
Subcellular Location Nucleus. Nucleus, PML body.
Tissue Specificity Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.

MAGE-A2B (N-18) - sc-130164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MAGE-A2 (133AT1218): sc-130164. Western blot analysis of MAGE-A2 expression in HL60 whole cell lysate.

Anti-MAGEA2 Antibody (N-Terminus, AP) - LS-C279068 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus, APC) - LS-C279069 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus, FITC) - LS-C279071 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus, Biotin) - LS-C279070 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus, Azide-free, HRP) - LS-C279072 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus, PE) - LS-C279073 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (N-Terminus) - LS-C327795 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGEA2 Antibody (aa23-72) - LS-C135649 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAGEA2 antibody LS-C135649 Western blot of Jurkat lysate.

Anti-MAGEA2 Antibody (aa81-108) - LS-C99933 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-MAGEA2 Antibody (clone 1H4) - LS-C197640 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H4
Western Blot analysis of MAGEA2 expression in transfected 293T cell line by MAGEA2 monoclonal antibody (M01), clone 1H4.Lane 1: MAGEA2 transfected lysate(35 KDa).Lane 2: Non-transfected lysate.

Anti-MAGEA2 Antibody (aa96-108) IHC-plus™ - LS-B883 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MAGEA2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B883 concentration 5 ug/ml.

MAGEA2 Antibody (1H4) - H00004101-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H4

MAGEA2 Antibody - NBP1-69033 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAGEA2 Antibody [NBP1-69033] - Titration: 0.2-1 ug/ml, Positive Control: Jurkat cell lysate.

Monoclonal Anti-MAGEA2 antibody produced in mouse - WH0004101M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H4
<B>Immunoblotting</B><BR/>Monoclonal Anti-MAGEA2, <B>Cat. No. WH0004101M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~35 kDa using Jurkat lysate.

Anti-MAGEA2 (288-301) antibody produced in rabbit - SAB1105476 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-MAGEA2 antibody produced in mouse - SAB1404044 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B1
<B>Immunoblotting</B><BR/>Monoclonal Anti-MAGEA2: <B>Cat. No. SAB1404044</B>: Antibody concentration: 1 μg/mL. Specific band of ~60.7 kDa using immunogen protein lysate.

MAGEA2 antibody - N-terminal region (ARP59881_P050) - ARP59881_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MAGEA2 antibody - GTX85647 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-MAGEA2 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX85647

MAGEA2 Antibody - N-terminal region (OAAB16513) - OAAB16513 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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